The Relationship Between Metabolic Syndrome And Liver Enzymes In Type 2 Diabetes

Objective:To explore the relationship between metabolic syndrome, liver enzymes and insulin resistance in type 2 diabetes.Methods:154 inpatients with type 2 diabetes in Sir Run Run Shaw Hospital from 2009 September to 2010 October were enrolled as controls. They were divided into two groups according to ATP-Ⅲcriteria, with or without metabolic syndrome. The differences of blood glucose, HOMA index, liver enzymes, lipids were evaluated.Results:The average level of liver enzymes in 86 patients without metabolic syndrome: ALT 17.7±8.5IU/L, AST 17.2±5.8IU/L, ALP 83.3±24.2IU/L, GGT 14.5±7.1IU/L; The average level of liver enzymes in 68 patients with metabolic syndrome:ALT 17.5±9.7IU/L, AST 18.8±6.7IU/L, ALP 78.1±24.1IU/L, GGT 19.1±13.5IU/L. Only the difference of GGT between two groups was statistically significant (P= 0.01). Hypertriglyceridemia (OR= 3.48,95% CI 1.56-7.78) and high HOMA-IR (OR= 3.54, 95% CI 1.34-9.35) are risk factors for elevated GGT. Conclusions:In type 2 diabetes, the level of GGT in patients with metabolic syndrome is higher than those without. This finding may be related to insulin resistance.