| Objective:Breast cancer is one of the most common malignant cancers of women. The prognosis of breast cancer patients with liver metastasis is poor. How to improve treatment efficacy and prolong survival of these patients is a challenge in clinic. The study aim is to explore the clinical characteristics, therapeutic strategies and prognosis agents of breast cancer liver metastasis patients.Methods:The tolal of 30 breast cancer patients with liver metastasis admitted to the Department of Medical Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University from Mar.2008 to Mar.2011 were studied. The data of patients were gathered, including clinical characteristics, pathological diagnosis, ER status, PR status, HER2 status, staging, adjuvant treatments,palliative treatments and survival agents.Results:30 patients were admitted into the study. The Median age of patients was 53.4 years, range from 35 years to 65 years. Firstly, we analysis the clinical characteristics ofⅠ-Ⅲstage patients, found that the onset age, TNM stage,ER status has correlated with PFS. The size of tumor, number of lymph node metastasis, menopause status can also impact PFS, but not reached statistically significant. The drug treatment combined with local treatment group has a longer MSR than drug treatment group (28.5m vs 32.8m, respectively). The liver metastasis prior to local metastasis or other organs has a poor prognosis(the survival time after metastasis or local recurrence 29.2m vs 73.2m respectively.P=0.044)Conclusions:Breast cancer patients with liver metastasis have a poor prognosis. The systemic treatment combined with local treatment is a Promising Strategy for the candidate patients, which may get a better survival. |
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