Part 1:Expression And Prognostic Significance Of The Matrix Metalloproteinase-11 By Tumor Cells And Stromal Fibroblasts In Invasive Ductal Carcinoma Of The Breast Part 2:Analysis Of Pathological Characteristics, Diagnosis And Treatment Of Breast Myofibrob

Purpose:To evaluate the expression of the Matrix metalloproteinase-11 (MMP-11) by tumor cells (TC) and stromal fibroblasts (SFB) in invasive ductal carcinoma (IDC) of the breast, and investigate the correlation between the MMP-11 expression in IDC and clinicopathological features, and whether MMP-11 plays an important role in breast cancer development and affects prognosis.Methods:In this study,285 invasive ductal carcinoma patient samples were collected from 2005 to 2008. MMP-11 expression was examined in TC and SFB by immunohistochemical staining, with clinical data and follow-up information from relevant patients collected. Subsequently, correlation analysis between MMP-11 expression and clinicopathological parameters was performed, in addition to evaluating the relationship between MMP-11 expression and disease-free survival/overall survival in IDC,luminalA subtype, Premenopausal/postmenopausal and axillary lymph node positive/negative breast cancer.Results:MMP-11 high expression by SFB was significantly correlated with Ki67 high expression (P=0.02,<0.05) and more advanced tumor stage (P=0.005,<0.05), while MMP-11 expression both by TC and SFB were significantly correlated with the occurrence of distant metastases (P<0.05). Multivariate analysis showed that MMP-11 expression in both tumor cells and stromal fibroblasts were independent risk factors affecting DFS (P<0.05), and MMP-11 expression by SFB was an independent risk factor affecting OS in IDC (P<0.05)MMP-11 high expression by TC was significantly correlated with the occurrence of distant metastases in luminalA subtype breast cancar (P=0.037,<0.05). Multivariate analysis showed that MMP-11 expression in SFB was independent risk factors affecting DFS and OS in luminalA subtype breast cancar (P<0.05)MMP-11 high expression by TC was significantly correlated with Ki67 high expression (P=0.025,<0.05) and the occurrence of distant metastases (P=0.001,<0.05). And MMP-11 expression by SFB was significantly correlated with HER-2 overexpession (P=0.000,<0.05), Ki67 high expression (P=0.024,<0.05), more advanced tumor stage (P=0.017,<0.05), and the occurrence of distant metastases (P=0.006,<0.05) in premenopausal breast cancer. MMP-11 expression by SFB was significantly correlated with the occurrence of distant metastases in postmenopausal breast cancer (P=0.000,<0.05). Multivariate analysis showed that MMP-11 expression in SFB were independent risk factors affecting DFS and OS in postmenopausal breast cancer (P<0.05)MMP-11 high expression by TC and SFB was significantly correlated with the occurrence of distant metastases (P<0.05), and MMP-11 expression by SFB was significantly correlated with Ki67 high expression in axillary lymph node positive breast cancer (P=0.013,<0.05). MMP-11 expression by TC was significantly correlated with the occurrence of distant metastases in axillary lymph node negative breast cancer (P=0.037,<0.05). Multivariate analysis showed that MMP-11 expression in SFB were independent risk factors affecting DFS in axillary lymph node positive breast cancer (P<0.05)Conclusions:MMP-11 expression was significantly related to clinicopathological parameters both by TC and SFB in IDC, Premenopausal and axillary lymph node positive breast cancer. MMP11 expression both by TC and SFB were closely associated with prognosis and significantly implicated as a potential predictive marker in IDC, luminalA subtype, Premenopausal/postmenopausal and axillary lymph node positive/negative breast cancer.Objective:To investigate the clinicopathological characteristics and treatment of breast myofibroblastoma (MFB)Methods:The clinical and pathological data of breast myofibroblastoma of 3 patients was reviewed abdominal surgery/Breast Surgery in our hospital from 1999 to 2014, to analyze the clinicopathological characteristics and therapy of this rare tumor.Results:All 3 patients were premenopausal women. MFB is presented by both palpation and imaging examintion as a solitary,unilateral,painless,freely movable nodule in all patients. All 3 patients were treated with tumor resection, and were confirmed by pathology as myofibroblastoma. In immunohisttochemistry, the expression of SMA, vimentin and desmin were positive, wherase the expression of S-100 was negtive. No postoperative adjuvant treatment were performed. All 3 patients were well recoveried and connected. By Oct.2014, neither recurrence nor metastasis was observed in all 3 patients at the following-up time.Conclusions:Myofibroblastoma of the breast is a rare benign stromal tumor in premenopausal women with a good prognosis. Tumor resection is the applicable treatment. The diagnosis must be based on pathological characteristics.Application of immunohistochemical markers (SMA,Vimentin,desmin and S-100) may be useful in the diagnosis.