| Liposome as a novel drug delivery system, it has many advantages such as targeting, protection, and sustained-release. Liposome has won the attention of more people in recent years. The following three aspects according to liposome were carried out in this paper:(1) Resveratrol liposomes obtained by hand-shaking method and ultrasonic-filming method were prepared firstly, then studied by SEM. Resveratrol liposomes and free drugs were separated using Sephadex G-50column and the entrapment efficiency was78.14%.(2) Particle size of Resveratrol liposomes are studied by laser granulometry. The average particle size of liposomes which obtained by hand-shaking method and ultrasonic-filming method were543nm and154nm. Liposome morphology was observed and liposome's experiment data was obtained by AFM. The rigidity of Resveratrol liposomes was determined by experiment data obtained by AFM and laser granulometry, and liposome obtained by ultrasonic-filming method was greater. Finally, a soft sphere model was established and we analyze the adhension and rigidity theoretically. Then we can get consistent results with the experimental observations after substitution of experiment data.(3) A small in-vitro system concerning how magnetic field affecting time and magnetic induction and gradient impact magnetic liposome circulating in human body was established. In this simulation system, fusion state of magnetic liposome circulating under various conditions was observed using AFM. Variation of magnetic liposome circulating under different magnetic affecting time and different magnetic density induction and gradient was obtained. Effectiveness of magnetic liposome made from different magnetic liquid was also discussed. |
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