Construction And Performance Research Of The Sensing Systems For Monosacchrides

Molecular recognition is one of the most attractive fields in organic chemistry. The recognition processes from the ions to simple molecules and complex biological molecular have attracted widely attention by chemists and biologists et al. With the development of modern science, the recognition of ion has not meeted the demand of social development. Molecular sensing of biological analytes with a metabolic function in living organisms has attracted extensive attention and well-designed recognition systems are crucial for high sensitivities.Saccharide molecules which have important function in organism were studied as our research object of the dissertation. The purpose is to get highly selectivity recognition system for monosaccharide and provides dependable basis for more complex life process and logical approach to the identification of clinical medical saccharide. Addtionally, we synthesised several indole derivatives which had important use in medicine and dye fields. This paper mainly includes five chapters as follows.Chapter 1:Briefly introduction of saccharide sensor and bring forward the topic of this paper.Chapter 2:Design and synthesis benzene-benzene water solubility organic polymer PPP-SO3-Na+ and three kinds of boric acid-substitude viologens quencher. The sensing actions of different sensing system to monosaccharides have been studied by fluorescence emission spectrum at physiological conditions. The results showed that the three combination systems (o-BBV/PPP-SO3-Na+,m-BBV/PPP-SO3-Na+ and p-BBV/PPP-SO3-Na+) had high selectivity and sensitivity for D-fructose. The detection range for D-fructose was from 1.0 mM to 200.0mM. The optimal ratios for fluorophore and quencher of the three system were o-BV/PPP-SO3-Na+ 3/1,m-BBV/PPP-SO3-Na+=1/1 andp-BBV/PPP-SO3-Na+=3/1, respectively.Chapter 3:Design and synthesis benzene-fluorene water solubility organic polymer FPP-SO3-Na+. The sensing actions of different sensing system to monosaccharides have been studied by fluorescence emission spectrum at physiological conditions. The results showed that the combination of o-BB V/FPP-SO3-Na+ and m-BBV/FPP-SO3-Na+ had higher selectivity for D-fructose. Additionally, although the system p-BBV/PPP-SO3-Na+ had selectivity for D-fructose, the signal of the recognition responsewas very weak.Chapter 4:Synthesis several indole derivatives.Chapter 5:Summary and prospects.