| Metal hydrolases which participates in many physiological activities, such as the hydrolysis of proteins, phospholipids, DNA and RNA play a very important role in the activities of life. How to use artificial methods to simulate the high activity and high selectivity of these enzymes has become a research hotspot in recent years. A variety of simple or model complexes have been used as the analog of natural hydrolase enzymes to get a deeper understanding of the relationship between the structure and the function. Imitation of enzymes lays the fundation for the designing, synthesis of simple, efficient, stable ideal catalysts.A new type of nitrogen, oxygen polydentate tripodal ligand and its zinc, copper and other transition metal complexes have been synthesized and preliminary investigation on their catalysis for the hydrolysis of ester have been carried out , the main works are as follows:Tripod ligand L was synthesized through the condensation of ethanolamine and (3,5-dimethyl-1H-pyrazol-1-yl)methanol. 1H NMR and IR spectroscopy were used to confirmed the structure of the ligand. The mononuclear zinc(II), copper(II) and nickel(II) complexes have been synthesized and their crystal structures were determined by single crystal X-ray diffraction. Copper complex has been chosen as a representative to investigate their biological activity in catalytic hydrolysis of esters. The results indicate that these complexes have some catalytic activity to ester hydrolysis. |
