Studys On The Preparation And Quality Standards Of Fajifulingtang Decoction Agent

Fangjifulingtang comes from the author of the Zhang Zhongjing's Glden Chamber pulse Card feature of aqueous vapor,By an Fangjifuling,poria,astragali,cassia twig,glycyrrhiza,five herbs ginseng composition,with invigorate the spleen,the effect of warming yang and promoting warming yang to promote diuresis,can be used to treat clinical of chronic nephritis edema,heart disease eden,and idiopathic edema and other diseases.This topic with Chinese medicine theory as a guide,a large amount of related literature inspection system,at the same time integrating drug clinical role,and the request of a new technology of herbal medicine,the shape of the medicine was reformed to a way of soup,eventually developed into fried cream, It's studied to abstraction technology of the material of the herbal medicine for a raw material,preparation technology,a district of a quality standard and the stability of preparation.Preparation:Take the ancient soup square's making craft as the basis, According to prescription medicines for each taste the chemical composition, physical and chemical properties,It's compared with tradition to modern abstraction technology.The rational abstraction technological line is established.Also experiment through a single factor,Absorbing water the medicine material the quantity carried on the investigation. The assurance the best soaks time; through L9 (34) orthogonal test, the amount of water, extraction time and extraction times were studied to determine the best extraction conditions, through the enrichment experiments,the pressure on the concentration, temperature and relative density of enrichment were investigated, and ultimately determine the appropriate concentration range of process conditions and the relative density;In model the craft research,It's inspected to the kind of accessaries and the amount of consumption, preferably take out a suitable accessory;It's studied to carry on the model product the craft and the pilot test,and established a scientific and reasonable preparation route.Quality Standards:To ensure quality of preparation and stability control,This topic mades ues of the modern system medicine technique,carried on the research to the quality standard on the Fangjifuling oria decoction Fried cream,and established Fangjifuling,astragali,glycyrrhiza TLC and the measurement of the content of the main ingredients in the Fangjifuling with the high-efficiency liquid chromatography. and the quality standards were established.Preparation of preliminary stability test: According to "Drug Registration" in the technical requirements, a preliminary stability test, respectively, at 0 months,1 month,2 months,3 months,6 months, regular review of decoction agent character, identification, content and other physical and chemical indicators of other aspects of testing, results showed that the basic stability of the indexes are in line with standards and the "Chinese Pharmacopoeia" 2010 version of a decoction agent under the relevant provisions.