Study On The Preparation And Quality Standards Of Xianjihuaban Capsules

Xianjihuaban capsule is composed of eleven Chinese medicinal herbs, which is an effective prescription to cure allergic purpura. It has the functions of cooling blood and arresting bleeding, activating blood circulation and dissipating blood stasis, and reinforcing qi and consolidating the exterior.Most of the active substances in the prescription and their pharmacologic action have been identified on the whole. Based on the former study results, this experiment extracted active substances according to their physical and chemical properties. The potential influence factors to the performance of extraction were fully considered. The techniques of ethanol extract and water extract were designed in scientific and reasonable way with orthogonal design.The Reasonable extract equipments and technique conditions were optimized by taking those representative effective constituents as criterion. Also, the process conditions of grinding, drying and formulation were studied before the processing parameters were determined.In order to guarantee the quality and curative effects of Xianjihuaban capsule, quality standard its set up was with the help of modern science and technology, such as microscope identification, TLC, UV and HPLC. After a series of experimental studies, two over three of all the herbs in the prescription were dentificated qualitatively, two herbs were controled quantitatively, and the quality standards were established.In addition, primary stability was tested in three lots of pilot study samples during the period of three months, and all the items covered the certification.The experimental result suggested that the technology ofXianjihuaban capsule convenient and feasible, the physical and chemical properties stable and the quality controllable.