The Circuit Modeling And Simulating Study Of The Upper Limb Vascular System

Cardiovascular disease is one of the most serious diseases which threat human's life, There are at least 230 million people with cardiovascular disease in our country, there are 3 million people who died of myocardial infarction, hemorrhagic stroke and other cardiovascular diseases each year, one third of death toll died of the diseases in the world. The disease can brought an enomous economic burden for the society and the family besides a high mortality rate. The directed medical costs more than 1300 billion yuan, accounting for over 22% of the total medical costs in the same period. So prevention and treatment of cardiovascular diseases in China has become an important health issue.Cardiovascular system is one of the earliest appliation in modeling and simulation.The mathematical model can be used to analysis and forecast the operation mechanism and regularity for changes of various physical illnesses. It can discussed the prevention of disease and the possibility of diagnosis under the implementation in artifical control, and developed various cardiovascular parameters methods and noninvasive tested medical instruments corresponding.The mathematical model methods used in this paper, mainly established a electrical circuits model of the upper limb and going ahead to simulate combined with clinical research. the main works in this paper are as follows.Firstly the basic knowledge of hemodynamic are intrduced, the development and situation of the electric network model in cardiovascular system are discussed detailedly, the classic single and double elastic chamber are analyzed and simulated, then the simulink model of the single and double elastic chamber are established .Secondedly, regarding the blood vessels as a number of small flexible pipes in series, three electrical circuits models of the upper limb are presented according to Windkessel theory. With Simulink and Simpowersystem of the matlab, the waveform of pressure can be simulated by the electrical circuits model. Comparing these three simulation models though clinical testing, an optimal electrical circuits model of the upper limb can be obtained .As hypertension and atherosclerosis is reflected by variations of dynamic parameters, we analyzed the influence on pressure waveform in radial artery when the parameters of the model changed. We studied the relevance between the parameters of model and the variation of the pulse wave in the two main disease cardiovascular system for hypertension and atherosclerosis. Compared the simulation and clinical test by ststistic methods, the effectiveness of the model can be shown in further.