Based On Ion Association Complex Drug Piezoelectric Sensor Applications

Piezoelectric quartz crystal (PQC) sensor has fOund itS extensive aPPlication invarious fields including analytical chemisny, electrochemisny, fore science, life..science, environmental monitoring and medica analysis because of its oUtStandngadvantaes such as high sensitivity, simPle conStruCtion, convenient operation andlow cost, etc..Wth the recent development of life science and medicine science. more andhigher requests are proposed for phannaceutical analysis. DrUg eleCtrdes are stillactive in phannaceutical area. For phannaceutical analysis, the best electrodes arethose based on ionTair comPlexes.Based on our previous work: drug electrodes and piezoelectric sensing, ionTairbased PQC sensors have been successfully develoPed. The elemenop responsemechanism of the proposed sensor was investigated and the resPonse model wasobtained. Influencing factors are investigated in detail and oPtimized. The analghcalresults of the phannaceutical preparations and the body fluids with the proposedsensors indicaed tha the sensors are easy-tO-hanle, convenient, sensihve, andreasonably selechve. The main work is surnmarized as fOllows:l. Non-potentiometric and, non-sPectrometric sensing method for thedeterminaion of pentoxyVerine and tetrahydropalmatine with PQC sensors based onionTair comPlexes.2. PreParation and aPplication of variablevalency drugs PQC sensors based onion-pair comPlexes. PQC sensors obtained much higher sensitivity and wider PHrange than the electrOdes based on Nemst Equaion.3. An elementary attempt has been made to enhance the signa-to-noise ratio ofPQC sensors using cholestyramine particles embedded in the sensing film. bormore, an all-purpose sulPha-drugs PQC sensor was developed Whch can be used forscreening Practice.