Compound Sanqi Granules Antithrombotic Effect Of Experimental Research

Purpose: to research the effects of Compound Notoginseng drug particles on clinical, hemorheology, coagulation function indexes in blood stasis rats model, and chemical thrombosis mice model of FeCl₃, and apply the disease model compound Notoginseng in the shamisen, traditional Chinese medicine granules for demolition-square analysis, discussion on his role to promoting blood circulation and removing blood, anticoagulative and antithrombotic and Optimization formula.Material and method:epinephrine injection twice with ice water bath to produce the blood stasis rats model, observe the hemorheology, four coagulation indexes and the blocking time of chemical thrombosis mice model of FeCl₃ by Compound Notoginseng drug particles. Granule of compound Notoginseng observed in mice tail bleeding time and coagulation time of impact; application of FeCl₃ mouse model of thrombosis chemical compound Notoginseng of the Notoginseng granules, red ginseng, amber for demolition of the shamisen, square analysis and the application of three factors two-level orthogonal experimental design factors, calculate the best ratio.Results:1. Compound Notoginseng granules could significantly prolong the FeCl₃ model of chemical thrombosis in mice plug into the time.2. Compound Notoginseng granules can blood stasis rat model permits the clinical appearance of reduced major indicators significantly improved blood rheology and fibrinogen levels decreased significantly.3. The best ratio of Notoginseng, red ginseng, amber is 2:1.5:1.Conclusion:1. Compound Notoginseng granules has obvious anti-thrombotic effect.2. Compound Notoginseng granules of the blood circulation has obvious role, which reduced fibrinogen levels related to the endogenous and exogenous coagulation pathway no obvious effect.3. The best ratio of Notoginseng, red ginseng, amber is 2:1.5:1.