Observation Of The Clinical Efficacy Of The Kidney And The Tune Liver Treatment Of Senile Depression

Object:Senile patients with depression is often associated with a variety of physical diseases, atypical clinical symptoms makes it hard to diagnosis. Regarding the treatment of several types commonly used in Western medicine side effects of drugs, the long-term use and efficacy is still not satisfied. Chinese medicine in the treatment of senile depression studies have shown good prospects, this study reinforce Kidney&Liver treatment of elderly patients with depression can be applied in clinical use. Compared with the syndromes, neuropsychological scale scores, PSQI scores, MoCA Scale scores and other indicators of changes and the condition of patients before and after treatment, to explore the role of kidney &liver adjustment mechanism.Methods:60 cases of senile depression were randomly divided into 2 groups, who came from Beijing University of Chinese Medicine, Dongfang Hospital.Delivery:western medicine group were given sertraline hydrochloride (Zoloft) Tablets,50mg/day/oral dose; Bushen-tiaogan tang Group were given decoction twice a day;SCALES:The core symptoms of depression to improve the situation, kidney deficiency syndrome Liver depression and to improve the situation, HAMD score, HAMA scores, PSQI score;Period:0,1,2,4,8,12 weeks respectively in drug delivery to evaluate the patients;Results:1. Bushen-tiaogan tang, compared with sertraline hydrochloride for the HAMD, HAMA reduction fraction was no significant difference; for PSQI and kidney liver Yu Scale significantly reduced rate of differences in sleep quality and improvement of kidney Liver depression syndromes, Bushen-tiaogan tang decoction is superior to sertraline hydrochloride group;2. Compared with sertraline hydrochloride on the HAMA scale scores there was no significant statistical difference in the two groups, but the onset time of the role of Bushen Tiaogan Tang 1 week, and significantly improves the physical symptoms; the onset time of sertraline hydrochloride 2 week,no significant fluctuations in 4-8 weeks as a platform for period, no significant change in patient's condition.sertraline hydrochloride, slightly better than Bushen-tiaogan tang 12 week;3. Compared with sertraline hydrochloride on the HAMD scale scores were there was no statistically significant difference, but the onset time of the role of Bushen Tiaogan Tang 1 week, and significantly improves the physical symptoms; the onset time of sertraline hydrochloride 2 week, Bushen-tiaogan tang acted a little slow but smoothly in 4-12-week, without any fluctuations;4. Visits the patients in this study group of syndromes with distinct characteristics of kidney liver stagnation syndrome, its symptoms include a number of aspects, in all cases, the frequency of more than 50% of the following symptoms:depression, Meditation does not gather, back pain, fidget, whole body fatigue. Bushen Tiaogan Tang for improving patient Meditation is not poly, whole body fatigue symptoms, significantly better than sertraline hydrochloride;5. Patients with sertraline hydrochloride showed gradual improvement in the first 4 weeks of the clinical symptoms, from 4-12 weeks, the medicine down the main symptoms, drug side effects to consider;6. The improvement of insomnia was also compared, Bushen-tiaogan tang significantly better than sertraline hydrochloride, while the improvement of cognitive function, both similar to and considering the relatively short observation period;Conclusion:1. Bushen-tiaogan tang can be effective in improving depression in old age depression, interest dull core symptoms; the same time, through the liver and kidney tonic to achieve the improvement of whole body fatigue, back pain or other symptoms of somatization;2. The stable effecite time is about 1 weeks, this study showed that no obvious siae effects. The safety has been verified;3. In term of insomnia, forgetfulness and other symptoms due to insomnia, forgetfulness and depression have a certain intrinsically linked, so these symptoms improved, depression can also been eased, which also shows that the reinforcement of liver & kidney is effective to improve the overall state of the body in elderly patients with physiological characteristics significantly reduced toxicity and the risks of combination therapy for patients with senile depression non-somatic symptoms of depression related to a certain degree of improvement.