Maodongqing To Interfere With The Inflammatory State Of Chronic Heart Failure

Chronic heart failure (CHF) rate is rapid growth trend, seriously threatened to human health. Chronic inflammation of-state in the process of the occurrence and development of CHF plays an important role in this paper, MaoDongQing chronic heart failure inflammation, research status effects of TCM prevention CHF mechanism.1 Theory researchCurrently, about the state of chronic inflammation in the occurrence and development process of CHF plays an important role in many scholars'attention. The basic consensus that chronic heart failure is an inflammatory reaction process and anti-inflammatory treatment becomes one important way CHF treatment. From the clinical manifestations, hf main points belong to the "surge" TCM syndrome, edema, "" palpitations" etc, the reason for this deficiency syndrome, Yang, qi difficiency and blood stasis water stops for standard. Treatment to temperatures promoting water, Yang fundamental index as the main therapy in clinical practice, the concrete application of many formulas have distinguishing feature each, can obtain good clinical curative effect. MaoDongQing medicine has qingrejiedu, invigorate the effect of arteries. In recent years, many scholars begin to realize, TCM therapy can be used not only CHF tonifying qi and blood, the methods such as water, can also according to CHF chronic inflammatory response intervene, modern pharmacology study shows that the anti-inflammatory and various cardiovascular pharmacology, combined with the previous clinical research foundation, we think MaoDongQing through its anti-inflammatory effect may improve CHF chronic inflammatory condition, thus to improve clinical symptoms of CHF and prognosis. So it is necessary MaoDongQing intervention in chronic heart failure state of inflammation, the experimental research on "qingrejiedu" method used in chronic heart failure and further promote the MaoDongQing used to treat chronic heart failure have important significance.2 Experimental researchObjective:to observe the MaoDongQing in chronic heart failure, the influence of initial state of inflammation "qingrejiedu" law of chronic heart failure mechanism. Methods:male SD rats 60 (weight) for 250±20g,48 randomized, for those who JiaShouShu group,12 for. Surgical method of the aorta in abdomen after aggravating heart failure model and load, and postoperative observation 30 days, the success of the rats were randomly divided into 4 groups, respectively MaoDongQing-low dose group, high dose group, western medicine (group) and enalapril). MaoDongQing low dose group MaoDongQing 10g/kg irrigation under/d, MaoDongQing high-dosage groups MaoDongQing 20g/kg irrigation under/d,5 fill 100mg captopril/kg/service; d, Control irrigation under physiological saline 2ml/d, Each byte is irrigation under two weeks after, observation, rats were generally heart ejection fraction (pa), cardiac function (heart), and blood type B natriuretic peptides (BNP), c-reactive protein (CRP), tumor necrosis for-a (TNF alpha) and interleukin-6 (IL-6), monocytes chemotactic protein-1 (MCP-1).3 Clinical observationCollect 10 patients with chronic heart failure patients and 10 cases of normal, cardiac function test c-reactive protein (CRP), B sex natriuretic peptides (BNP), with chronic heart failure and discussed the relationship between inflammation index.4 Results:(1) JiaShouShu group of cardiac (BNP), FS and EF significantly better than control group (P< 0.01), the success.(2) rat experiment shows that MaoDongQing high-dosage groups, low dose group and enalapril group can improve the rat cardiac function in three groups, FS value EF BNP value change, and no significant differences between groups (P> 0.05), among similar effect. Through the comparison with the control group, MaoDongQing high-dosage groups in improving EF value and has low value FS group, the trend of the low-dose BNP value in improving is superior to the trend of high dose group.(3) As for rat on inflammatory index of serum test, MaoDongQing lower dose treatment of rats, TNF alpha CRP, IL-6-1 with MCP, captopril cessation between implant and sham group had no significant difference, also significantly lower than that of control, high doses of rats, although also see index dropped significantly, but the inflammation as low doses groups.Clinical observation (4) found in hf patients with CRP were higher than the BNP hf patients (P< 0.05). Conclusion:(1) On rats can cause abdominal aorta ligation of chronic heart failure model of success.(2) MaoDongQing can improve cardiac function in rats.(3) MaoDongQing can improve chronic heart failure rats, and inflammation of the state, with low doses of similar captopril.Patients with chronic heart failure (4) exist with the increase of BNP CRP, chronic heart failure exists inflammatory reaction.