Maodongqing 18 - Dehydrogenase -20 - Table - Experimental Study And Mechanism Of Ursolic Acid Antithrombotic Discussed

Objective: TO observc pharmacological effects of Ilexolic acid(1La) on thrombosis and its mechanism.Metbods: Time occlusive thrombosis time(OT): Weigh moistweight ofthrombus: Test ELT. PT. KPTT: Measure maximumplatelst aggregation rate in 5 min (MPAR5M) using TYXN-91Amodel automatic blood agglutinate appliance: 6-keto-PGF1a andcAMP were measured by radioimmunoassay.Results: ILa(20. 40. 80mg.kg') inhibited significantly thrombosisof artery and vein in rat. lLa (25. 50mg.kg-i) inhibited obviouslyplatelet aggregation induced by ADP and collagen in rabbit, ILa(20.40. 80.g.kgi) increased markedly fibrinolysis and PGI2 in arterysmooth muscle cell in rat. ILa(3. 6mg.ml-'PRP) can increase cAMP inplatelet in rat .ILa(20. 40. 80mg.kgi) decreased markedly peripheralresistance witk rat lower limbs artery bcing poured into at constantvelocity ILa(20. 40. 80mg.kg-') had no effect on intrinsic coagulationsystem and extrinsic coagulation system.Conclusion: ILa had effects of inhibiting thrombosis'inhibiting platelet aggregation as well as increasing fibrinolysis anddecreasing peripheral resistance. It is suggested that inhibitingplatelst aggregation was concerned with increasing PG12 and cAMP.