| Stress ulcer is a body in the subject of emergency,stress or strong performance when the external role of a stress response, by inflammatory erosion,superficial ulceration and gastrointestinal bleeding acute gastric mucosal lesion characterized. In stress state (including the various wound,critical disease) occurring in acute gastroduodenal mucosal erosion and ulceration, is a severe stress reaction, exists in all life-critical patients, such as cerebral hemorrhage,shock,empyrosis,severe trauma,major operation,severe systemic infection,etc, can cause gastrointestinal bleeding and perforation, a high mortality rate. Currently, the incidence of stress ulcer on the rise, attracted widespread attention.The disease belongs to traditional Chinese medicine."stomachache" aspects of the "swallowing acid","noisy" and other closely related. In recent years, Chinese medicine in the prevention and treatment of stress ulcer aspects of a large number of experimental studies and clinical research, and made some progress. Studies have shown that acupuncture can not only promote the local ulcer healing, but also effectively regulate the functional status of the entire body, from the various promote ulcer healing, reduce recurrence.The acupuncture and moxibustion has the effect clearing meridians, mediating Yin and Yang, strengthening body resistance and eliminating evil. Recent studies have shown that acupuncture can clear the meridians,transfer gas,mental adjustment, affect the neuroendocrine immune network in the release of neurotransmitters and hormones to increase body resistance to stress damage the ability of, this is acupuncture and moxibustion prevention and treatment a stress disease one of the important mechanism. Acupuncturehas and moxibustion has a healthy two-way regulation, through multi-level,multi-channel,multi-tool to adjust the body to achieve comprehensive protection of gastric mucosa aim to achieve the treatment of gastric ulcer.Objective:Through the establishment of rat stress ulcer model, the model rats acupuncture prevention and treatment, observed the model rat stomach mucous membrane pathological mechanism form and organize change, check the contents of blood plasma and and hypothalamus in the endogenous opioidβ-endorphin (β-endorphin,β-EP), discuss the role of acupuncture in the prevention and treatment of SU, from the laboratory shows on intervention in the prevention and treatment of acupuncture's clinical significance of SU, so as to provide a basis for clinical guidance. Method:After adaptation to the environment, the model animals were randomly divided into control group, model group 1, treatment group, model group 2, prevention group,8 in each group. Adopt alcohol law to bring about stress ulcer model in rats. After modeling, the treatment group before acupuncture, acupuncture prevention group, after first modeling; Model group 1 and model group 2 modeling time was the same treatment group and prevention group.Points elected Zusanli (ST 36),Zhongwan(RN 12), Neiguan(PC 6). After the operation, measurement cardia lose an exponent to the anus part overall length and last forward position of charcoal calculating the size pushing forward a percentage, determining the ulcer cooking stove, calculated mucosal damage index, and plasma and hypothalamus ofβ-endorphin content.Results:Compared with model group, prevention group of rats significantly increased the percentage of gastrointestinal motility, the difference was significant (P <0.05); Compared with model group, treatment group and prevention group of rats significantly reduced gastric damage score, the difference was significant, (respectively, P<0.05, P<0.01); Compared with model group, treatment group and the prevention of plasma P-EP were significantly lower, the difference was significant respectively (P<0.05, P<0.01); Compared with model group, treatment group and prevention group of hypothalamic P-EP content in significantly increased, the difference was significant (P<0.01).Conclusion:The experiment shows:①Acupuncture can protect the gastrointestinal system, improve the percentage of gastrointestinal motility.②Rat model of acupuncture on SU affect food intake, which is acupuncture ulcer repair.③Acupuncture can relieve ulcer rats with lesions SU inflammation, relieve bleeding, and promote ulcer.④Acupuncture can decrease the plasmaβ-EP levels, suggesting that acupuncture can promote plasmaβ-EP in the transfer to the organization, thereby reducing inflammation and promoting ulcer repair.⑤Acupuncture can increase hypothalamic levels ofβ-endorphin, regulate stress stimulated by the hypothalamus-pituitary-adrenal axis, thereby promoting healing of ulcers.⑥acupuncture have preventive and therapeutic effects on SU. Experiment from the lab shows the acupuncture intervention in the prevention and treatment of SU's clinical significance, so as to provide some basis for clinical. |
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