Experimental Study Of The Effects Of Electricity For Perimenopausal Depression In Rat Behavior And Brain ¦Â-endorphin And Other Indicators

Purpose:Observation of Electroacupuncture on perimenopausal depression in rat behavior and brainβ-endorphin content;explore acupuncture treatment of perimenopausal depression mechanism of action.Material and methods:4-month-old 10 female SD rats,body weight(150～200) g for the young group;11～15-month-old female SD rats of 45,weight(250～300) g,high to low grade according to the weight,according to random number table is divided into 3 groups:model group,electro-acupuncture group,western medicine group,through the unpredictability of chronic stimulation,the establishment of peri-menopausal rat model of depression.Needle electro-acupuncture group,"Baihui","Sanyinjiao","Shenshu","Ganshu,:1 a day, for 1 week;Western medicine group 5m/kg oral clomipramine treatment;youth group and model group,given only to stimulate crawling.In the previous model,before and after treatment,the use of open-field experiment(open-Field) method Test, 1 week after treatment using ELISA method on brainβ-endorphin,serum estradiol testing and analysis.Results:1.Open-field test,the model group and youth group,the horizontal movement, vertical movement level decreased significantly(P＜0.01);treatment, electro-acupuncture group and model group,western medicine group and model group,respectively,compared to the level of exercise,level of vertical movement(P＜0.05);treatment,electro-acupuncture group and western medicine group,the horizontal movement,vertical movement was no significant difference (P＞0.05).2.Model group and youth group,serum estradiol,cerebralβ-endorphin significantly increased(P＜0.01);treatment,electro-acupuncture group and model group,western medicine group were compared with model group,serum estradiol,cerebralβ-endorphin increased significantly(P＜0.05);Treatment, electro-acupuncture group compared with the western medicine group serum estradiol,β-endorphin content in the brain was no significant difference (P＞0.05).Conclusion:1.Acupuncture can improve the rat brainβ-endorphin content and improve the content of serum estradiol to improve perimenopausal depression,behavioral changes in rats.2.Acupuncture maybe achieve the treatment of perimenopausal period of depression by regulating the content ofβ-endorphin in the brain.