Detoxification Through The Liver Scattered Network Tune Experimental Obese Diabetic Rat Model

Type 2 diabetic mellitus(T2DM) is belonged in Traditional Chinese Medicine(TCM) XiaoKe-Disease. Insulin Resistanc(IR) is an important one of pathogenesis and it is the characteristic of T2DM. Systematic studies on the prevention and treatment for T2DM,IR by JieDuTongLuoTiaoGanSan(JDTLTGS) had been performed from the aspects of reference reviews, theory discussion and experimental study in this essay. It layed stress on that the main mechanism of T2DM is"Method of Removing toxin, activating collateral and regulating liver",exploring the relation between"Method of Removing toxin, activating collateral and regulating liver"of T2DM,IR .While"Method of Removing toxin, activating collateral and regulating liver"being scientific is illustrated from a different angle. And through experimental study, we discovery that JieDuTongLuoTiaoGanSan can relieve IR and increase sensibility for insulin . It can prevented and controlled on T2DM, IR ,It has strong innovation and usability.1 Reference review1.1 The skeleton research of TCM on T2DM,IRThis essay reviewed from the advances of such fields as followed: the source and name of TCM for T2DM,IR,the etiology and pathogenesis for T2DM,IR , selection of treatment based on the differential syndrome diagnosis, the pathogenesis of TCM on T2DM,IR, which is in ancient and modern times, moreover, included the evaluations and prospects on the problems lying in the selection of treatment based on the differential syndrome diagnosis or scientific study.1.2 The latest study of pathogenesis of T2DM,IRThe results and progresses of study on glucose and lipid metabolism,inflammatory pathogenesis were summarized involving of T2DM,IR at home and abroad in recent years.2 Theory StudyBy discussing the pathogenesis theory, principle and method of treatment of XiaoKe Disease with Chinese medicine theories quoting from the Chinese classics works,we put forward the theory that the main mechanism of XiaoKe Disease is"Method of Removing toxin, activating collateral and regulating liver".By combining modern research result, we put forward the theory that the main mechanism of IR is liver. Theory gist of treating XiaoKe Disease is provided by us discussing the effective way of"Method for removing toxin, activating collateral and regulating liver"of T2DM,IR. It discusses the"Method of Removing toxin, activating collateral and regulating liver"is provided with scientific to improve IR and prevents T2DM.3 Experimental studyThe influence about JDTLTGS in the experimental diabetic ratsHigh fat and glucose food and STZ-induced diabetic rats were divided randomLy into normal control group, diabetic model group, positive control group (DM+metformin,DM+pioglitazone), experimental group (DM+JDTLTGS) in Chinese herb. The various marks were observed. The results showed JDTLTGS obviously improve the rats'general condition and had a certain effect on reducing blood glucose, improve IR ,increasing insulin sensitivity index, which had a significant statistic sense in comparing with diabetic model group (P<0.01).Besides it could lighten weight, reduce liver index,AST,ALT, which had a significant statistic sense in comparing with diabetic model group (P<0.01).It also serumed cholesterol (TC) and triglyceride (TG), the level of free fattty acid in blood and liver tissue. which had a significant statistic sense in comparing with diabetic model group (P<0.01). The results indicated that JDTLTGS was beneficial for regulating glucose and lipid metabolism, improve IR ,increasing insulin sensitivity.4 Clinical studyThe clinical observation about JDTLTGS treat 35 person suffering from T2DM The research about JDTLTGS interfere with T2DM blood sugar, the body weight and inflammation designated object C response protein (CRP), the uninuclear cell hastens the protein 1(MCP-1) level influence.We divide 70 person suffering from T2DM into the Chinese medicine treatment group and the medicine contrast group equally。the treatment group takes JDTLTGS, the contrast group uses metformin, The treatment course is 4 weeks.The contrast observes around two groups of clinical curative effects and the treatment the blood sugar, the blood fats, the body weight index, the inflammation designated object change.The treatment group curative effect surpasses the contrast group; JDTLTGS have good curative effect for improve level of the blood sugar, the blood fat ,it also reduced CRP and MCP-1 levels.