A Bead Of Liver Fibrosis In Rats Of Pdgf, Tnf-alpha, Il-6

Objective: A treatment beads The efficacy of hepatic fibrosis. Methods: Wistar rats were divided into 60 normal control group, the model group, colchicine group, Chu A high, medium and low-dose groups, each with 10. Group 1 control group given ordinary feed, the normal drinking water, not to impose other human factors. Group 2 model group, according to CCl4 modeling methods to diet; Group 3 colchicine group, in the first three weeks of modeling started to colchicine 0.1 mg / (kg·d^-1), the rest of the group made module on the basis beginning in the third week by 2.0 g / kg·d^-1; 1.0g/kg·d^-1; 0.5g / kg·d^-1 for the administration of a suspension beads gavage. 1st day. A total of eight weeks time.Last gavage, the animals were fasted for 12 hours, abdominal aortic blood and liver weight. Through the ALT liver fibrosis in rats, ALP, MAO, TNF-a, IL-6 and PDGF testing of a protective JiangMei beads, and the role of prevention and treatment of liver fibrosis.Conclusion: A rat liver fibrosis beads on the pathology of the liver, liver function, cytokines (TNF-a, IL-6) level of PDGF a marked improvement on the role of the intensity and concentration, the statistically high dose group of the most notable effect in the rat biochemical indicators, a superior colchicine group beads. A note of the beads have a good or inhibition of hepatic fibrosis. Role.