Acute Coronary Syndrome Intervention Postoperative Tcm Syndromes And Physical And Chemical Indicators

Objective:This study was designed to investigate the Traditional Chinese medicine (TCM) syndromes distributions of the acute coronary syndrome(ACS) patients after percutaneous coronary intervention(PCI) with the epidemiological method supported by the National 973 plan grant,"the systematic research of etiology between cardiovascular thrombotic disease and the stasis and toxins(a concept of TCM theory)",and explore the correlation between the TCM syndromes and the physical-biomarkers indexes for the establishment of 'the stasis and toxins' and the reference for the TCM syndrome differentiation.Materials and methods:We selected randomly 430 cases with ACS(male 315,female 115,mean age 62.15±8.62 years) after PCI in Anzhen Hospital,all of them were consistent with the including and excluding standards,159 cases of them are(male 122,female 37) completed the period of 6-month follow-up.This study recorded medical history,symptom, pip,pulse conditions,etc.for all patients.Syndrome differentiation was identified by two doctors majoring in integration of Chinese and Western cardiological medicine.The pip graph was recorded by Canon IXUS860 digital camera.Upper limb venous blood when in empty stomach condition was collected on the follow-up day.The blood was tested by the laboratory of Anzhen Hospital including blood routine and biochemical indicator.High-sensitivity C-reactive protein(Hs-CRP) was tested by enzyme-linked immunosorbent assay(ELISA); Total cholesterol(TC) was tested by CHOD-PAP and Triglyceride(TG) was tested by GPO-PAP.High density lipoprotein cholesterol(HDL-C) was tested by PTA-Mg2+.Low density lipoprotein cholesterol(LDL-C) was tested by PVS.Fibrinogen(Fg) was tested by CLASS.The patient message was input into the database.SPSS13.0 software was used to clean and analyze the statistic.Results:1.The proportion of each syndrome is blood stasis(57.2%),phlegm stagnancy (50.0%),Qi deficiency(41.4%),the Yin deficiency(21.2%),Yang deficiency(15.1%), stagnancy of Qi(8.8%) in a descending sequence at the first follow-up time.The proportion of each syndrome is blood stasis(61%),phlegm stagnancy(48.4%),qi deficiency(40.3%), Yang deficiency(24.5%),the Yin deficiency(19.5%),stagnancy of Qi(8%) in a descending sequence at the second follow-up time.The proportion of Yang deficiency syndrome was raised obviously during the six months.2.The Hs-CRP level of Yang deficiency syndrome is obviously lower than that of non-deficiency of Yang patients(P＜0.05 ).The Hs-CRP level of stagnancy of Qi syndrome is obviously higher than Qi deficiency,Yang deficiency,blood stasis and phlegm stagnancy syndromes(P＜0.05).The Hs-CRP level of blood stasis syndrome is obviously lower than phlegm stagnancy,stagnancy of Qi and Qi deficiency syndromes(P＜0.05).3.The PLT and PDW level of blood stasis syndrome is obviously higher than non-blood stasis syndrome(P＜0.001).4.The Fg level of male patients is obviously lower than female patients(P＜0.05).The Fg level of drink patients is obviously lower than non-drink patients(P＜0.05).5.The LDL-C level of blood stasis syndrome is obviously lower than non-blood stasis syndrome(P＜0.05).The HDL-C level of phlegm stagnancy syndrome is obviously lower than non- phlegm stagnancy syndrome(P＜0.05).6. The RBC level of phlegm stagnancy syndrome is obviously higher than non- phlegm stagnancy syndrome(P＜0.05 ).The HCT level of phlegm stagnancy syndrome is obviously higher than non-phlegm stagnancy syndrome(P＜0.05).The HCT level of phlegm stagnancy syndrome is obviously higher than stagnancy of Qi and Yang deficiency syndromes(P＜0.05).The HCT level of Yang deficiency syndrome is obviously lower than blood stasis syndrome(P＜0.05).Conclusion:1) The blood stasis syndrome and phlegm stagnancy syndrome are the main syndromes of the patients with ACS patients after PCI.The proportion of blood stasis syndrome and Yang deficiency syndrome rises as time goes on.Deficiency and excessive appeared at the same time and the syndrome system of the ACS patients after PCI can be built. Academician Ke-ji Chen used to treat the CAD patients through the principles of dredge and supplementary.The rationality of this theory can be deduced by this study.2) The significant changes of Hs-CRP level on stagnancy of Qi and Yang deficiency syndromes,makes it is possible for Hs-CRP to be one of the objective diagnosis indexes for stagnancy of Qi and Yang deficiency syndromes,but it remains to be confirmed.3) The significant rise of PLT and PDW levels on stagnancy of blood stasis syndrome, make it possible for PLT and PDW united to be one of the objective diagnosis indexes for blood stasis syndrome,but the fixed value remains to be confirmed.4) It proves that moderate drinking could lower the level of Fg,and may be beneficial to microcirculation.5) The significant decrease of HDL-C on phlegm stagnancy syndrome,make it possible for HDL-C to be one of the objective diagnosis indexes for phlegm stagnancy syndrome.6) The significance rise of RBC and HCT levels on stagnancy of phlegm stagnancy syndrome,make it possible for RBC and HCT united to be one of the objective diagnosis indexes for phlegm stagnancy syndrome.7) It was proved that Over-weight and over-waist are significant dangerous factors for ACS patient by this study.