Head Wind More Diwan Migraine Prevention Effect And Mechanism Of Study

In order to discuss the mechanism of Tou-feng-yu dropping pill as a medicine used to treat migraine, the following experiments were done: building up animal models with migraine caused by nitroglycerin-migraine and exhausting 5-HT respectively; vein experiment in vitro; blood flow measurement; meninx microcirculation test; anti-platelet aggregation and anti-thrombosis in vitro and in vivo; and analgesic effect experiments. Based on these experiments above, animals' behavior respondences to the drug, the drug's effects on neurotransmitter, neuropeptide and Vasoactive substances et al. were observed.According to these experiments, the pharmacological mechanism of Tou-feng-yu dropping pill has been summarized as follows:(1) Affecting the content of neurotransmitter (5-HT, 5-HIAA, DA, NE), neuropeptide (CGRP, ET) and Vasoactive substances (NO, NOS, TXB2, 6-keto-PGF_1a) of animal models; decreasing the release of substances resulting in pain and inflammation; reducing further impairment of nerve cell and cerebral vessel and preventing risk of neurogenic inflammation.(2) Improving vasomotoricity of experimental animal; dilating vein; increasing cerebral blood flow; decreasing cerebral vascular resistance and improving meninx microcirculation.(3) Relieving abnormity of hemorheology; inhibiting platelet aggregation; preventing thrombosis and reducing the release of 5-HT.(4) Raising the pain threshold of mouse and helping relieve or prevent the risk of headache.