Polyphenols Dispersible Tablets Of The Pharmaceutical Research And Preliminary Efficacy Study

The tea polyphenols dispersible tablet comes from tea leaves extractive—tea polyphenols, using to cure jejuni bacterial infection.Through analyzing the related literature ,on the basis of the function and treatment as well as clinical medication requests, studied the quality tea polyphenols'criteria,quality standard,stability,initial pharmacodynamics experiment of the crude drug.This study determined the quality standard of the tea polyphenols crude drug. In the preparation route, selecting the disintegration time as the index, use one-facor experimental design and orthogonal experiment to optimize the preparation parameter, such as the type,dosage and the adding way of the adjuvants. The quality standard study using Physical and Chemical identification method to identify the tea polyphenols and testing its dissolution,also established the content assay method for Polyphenols and the quality standard. In the stability study was done to the 3 bacths of semi-works production for 3 months,and every indicator accoded with the definition. The pharmacodynamics experiment using tube dilution method determined the MIC,Salmonella 6.25mg/ml is and Campylobacter jejuni 25mg/ml.A systematic study on the procedure,quality standards and the preliminary pharmacodynamics on The tea polyphenols dispersible tablet has been carried out .it is a good basisi for register of new medicine.the pharmaceutics is effect to Salmonella and Campylobacter jejuni.