Preparation Of Duyiwei Dispersible Tablet

Lamiophlomis rotata Kudo belongs to Lamiophlomis rotata Kudo genus is a popular national folk herbal medicine in China's Tibetan,Mongolian,Naxi and other nations.It can be used to promot blood flow, relieve pain , remove blood stasis , hemostasis and so on .In recent years, it has more people's attention.Now it is widely used in clinical because of it has many good effects and have no toxic side effects. Duyiwei total flavonoids is the effective analgesia site of Lamiophlomis rotata Kudo, can be used for clinical treatment of orthopedics fractures caused by pain, rheumatism pain,the first step pain medicine for cancer and so on.At present,Lamiophlomis rotata Kudo has only capsule and tablet on the market.Now they have can't meet the clinical requirement for immediate effects and high performances,for the collapse and dissolution is slow, capsule shell is easily dehydrates for absorption extend the rate of collapse.In recent years,dispersible tablet is a new fast-release solid dosage form,has many good qualities,better decentralized state,shorter collapse time,rapider dissolution,faster absorption,bioavilability and it is easy to take ,can be swallow ,drink with water and chew,so it is popular with elderly patients and patients with dysphagia. The research to change Duyiwei capsule to dispersible tablet can reduce dosage,increase drug action and rich dosage form.The procedure will be describe as follows.1.Determine the content of Duyiwei total flavonoids by ultraviolet- spectrophotometer.The optimize water extract processing were selected by orthogonal experiment. 2.Use macroporous resin to rich and pure Duyiwei total flavonoids,and get the process condition and parameters.Through study the absorption and desorption properties of the four kinds of macroporous adsorptive resin with static absorption capacity,static indicators washout rate,the AB-8 determined as the best resin to separation and purity the total flavonoids.Through study the sample pH value,sample concentration,adsorption rate,washed dosage,elution concentration,eluate rate and the end of elution ,the optimize absoption and desorption condition were determined.3.Flit the Duyiwei dispersible tablet optimize prescription and determine the prodution technology by choose the accessories with parallel experiment. Verify the prodution technology is easy,suitable for industrial production and have good repeatability by three batches experiment.4.Establish the Duyiwei dispersible tablet quality standard by inspect the quality.The production quality standard is proved easy to be controlled by determine the content of Duyiwei total flavonoids and luteolin by three batches experiment.5.The quality standard were proved Duyiwei dispersible tablet have good stability through determine content of sample by accelation stability and long-term stability experiment.6.The pharmacodynamics study of Duyiwei dispersible tablet showed it has good analgesic and anti-inflammatory roles and hemostasis and have minimal toxicity through mouse hot plate,acetic acid writhing law and xylene mouse ear swelling and mouse tail bleeding experiment.On the whole, Duyiwei dispersible tablet has a good development and application perspect for it is suitable for industrial production, controllable in quality standard and have precise drug action,low dosage,high bioavilability.