Children With Cerebral Palsy Clinical Tcm Syndrome Phenology Survey And Intervention Study Of Chinese Medicine

Cerebral palsy(CP) is an umbrella term encompassing a group of non-progressive,non-contagious conditions that cause physical disability in human development.CP is caused by many harmful factors in prenatal period.or labor and postnatal period and can lead to the movement nerve function obstacle.The main clinical manifestations are centor-dyskinesia and posture abnormality.It is often accompanied by mental retardation and vision disorder,acoustic disorder,speech disorder and epilepsy.We start from the theoretical research,and through clinical and experimental studies on the characteristics of Chinese syndromes and research about the motor dysfunction caused by CP,in order to give better play to the Chinese medicine treatment,and lay the foundation for the motor dysfunction of Differential Treatment of CP.1.Theoretical StudyWe study the motor dysfunction caused by CP based on the theory of liver-wind stirring of TCM,which epitomizes the pathogensis and symptons of endogenous wind.Endogenous wind is an abstract concept.Liver-wind stirring can be judged when the patients feel the characteristics symptoms like vertigo,convulsions or tremor can be judged to that.Cerebral palsy affects the central nervous system.Most children suffering from CP can be found having abnormal gesture,muscular tension or involuntary movement.Clinical symptoms of cerebral palsy differ from each other.We study the links between various types of movement disorders and various types of liver-wind stirring.2.Clinical StudiesWe selected 90 children with CP,with ages varying from 4 to 12 years old and observed their the Chinese Syndromes of CP,combining with the evaluation of the gross motor function,and conducted a relevance study between the Chinese syndromes and these evaluations.The key elements are as follows:□2.1) Studying the characteristics of Chinese Syndromes on children with CPWe used the clinical survey on children with CP to observe their Chinese syndromes.There are 50 syndromes with occurrence rate more than 15 percent. In the research,the syndromes from the first to the tenth were deficiency of kidney-essence,deficiency of spleen-Qi,liver-wind stirring,deficiency of □kidney-yin,obstruction of brain Luo,gastric heat,deficiency of lung-QI, deficiency of liver-yin,stagnation of qi of the stomach intestine and mental confusion due to phlegm.The tendency is the frequency of the deficiency syndromes was higher,and accompanied with the sthenia syndromes,such as phlegm,blood stasis,moist,heat,stagnation of the qi,and so on.□2.2) Related research on gross motor function evaluation and Chinese syndromes of CPIn this study,we used the clinical survey of children with CP and the gross motor function measure(GMFM).The result showed there is no obvious difference between the children of the spastic cerebral palsy and athetosis cerebral palsy in GMFM score and GMFCS score.However,going deeper into the research,we found that motor function of lower limb in case of athetosis CP is better than that of spastic CP and the motor function of upper limb of spastic CP is better than athetosis CP.There is a negative correlation between the gross motor function and the Chinese syndrome,the syndrome of deficiency of kidney-essence,deficiency of spleen-Qi,endogenous liver wind and deficiency of kidney-yin were intimate with the gross motor functional disturbance of CP.3.Experimental StudiesWe evaluated the neuroethology changes through establishing animal models of CP.We use different Chinese herbs to intervene for animal models in order to investigate their roles in medicine mechanisms.Main content and the results are as follows:□3.1) Establishing rat model of sports fatigueWe established CP animal model by LPS peritoneal injection leading to intrauterine infection.The neuroethology evaluations were done on the neonate rat,which were looked on as the sieve standard of the CP animal model.After the neuroethology evaluations,we carried out the HE drum dyeing on the brain section of neonate rat.The result showed,the sieved CP rats were appeared as reaction clumsy,voluntary movement decreasing, abnormal gesture and motor stability decreasing,and some of the CP rats occurred thrill and hyperspasmia.These appearances were consistent with the neuroethological characters of CP.We then proceeded with the HE drum dyeing on the brain section of the CP rats,the result of which showed that the brain damage were consistent with the pathological changes of CP. □3.2) Assessing the ethology changes of the CP rats under the effect of the Chinese herb medicines intervening on.In this part we use neuroethological examination,which included the slopes reflect experiment,suspension experiment,Tarlov score,Ashworth score,to observe the changes of the motor function of the CP rats and the effect of the Chinese herb medicines "Large Wind-Expelling Decoction" and "Bu Zhong Yi Qi soup".The result showed that as the rats of"Bu Zhong Yi Qi soup" group,whose voluntary movement score and gestorc score and animal force increasing,muscular tension descending,and still had involuntary movements.As the rats of"Large Wind-Expelling Decoction" group,whose voluntary movement score and gesture score and animal force increasing,muscular tension descending,and had no involuntary movements. We can make the conclusion through the therapy of"reinforce the spleen to restrain the abnormal function of the liver",the agonist muscle force can be elevated,and oppose the antagonistic muscle,and improve the gesture or voluntary movement.Through the therapy of"nourishing Yin of liver and kidney",the abnormal state of muscle spasm and involuntary movement can be improved.4.SummaryIn theoretical study,we study on the theory of liver-wind stirring of TCM connect to various types of movement disorders caused by CP.In clinical studies,we observed Chinese syndrome of CP,combining with rehabilitation assessments.We studied the relevance of Chinese syndromes and gross motor functions.In the experimental studies,we established rat model of CP,and assessed neuroethological ability of the animal model.Then we use different Chinese herbs intervening animal models in order to investigate the role of drug mechanisms and the model's characteristics of Chinese Syndrome.All the studies give a positive role to the characteristics of Chinese medicine treatment and lay the foundation for studying differential treatment of motor dysfunction of CP.