Coptis Evodia Compatibility Lipid-lowering Substance Basic Research

Objeetive:Coptidis rhizoma means the arid rhizoma of Coptis chinensis Franch,Coptis deltoidea C.Y.Cheng et Hsiao or Coptis testa Wall.Which belongs to Ranunculaceae;Fructus Evodiae means the approaching add ripe fruit of Evodia rutaecarpa(Juss.) Benth.,Evodia rutaecarpa(Juss.) Benth..var.officininalis(Dode) Huang or Evodia rutaecarpa(Juss.) Benth..var.bodinieri(Dote) Huang,which belongs to Rutaceae.Zoological experiments and clinical experience shows that the compatibility of Coptidis rhizoma and Fructus Evodiae leads to conspicuous Fat-degrade effect.The topic imitates to carry out gradiently elution of the four proportionality of(1:1),(2:1),(6:1),(1:6),which is plan to research the relationship between the atlas and the pharmacodynamic action.Besides comparing the increasing and decreasing of the index ingredient that before or after the compatibility.Associating and comparing the chemical and zoogenic experiments,the topic is plan to study the Fat-degrade effect,and to establish foundation for ulterior study.Methods:With Coptidis rhizoma,(1:1),(2:1),(6:1),(1:6) for investigative objects,to make the contents of Coptidis rhizoma in monogastric volume to equal;and with Fructus Evodiae,(1:1),(2:1),(6:1),(1:6) for investigative objects,to make the contents of Fructus Evodiae in monogastric volume to equal.Use HPLC to carry out gradiently elution in 60 minutes for qualitative and quantitative studies about the ingredients of every object and the regularity of changing.Results:When the contents of Coptidis rhizoma in monogastric volume is equal, Fructus Evodiae makes the contents of Coptidis rhizoma decreased.What is decreased is related to the proper contents of Coptidis rhizoma.The proper contents of Coptidis rhizoma is more,which decreased is more,besides the remaining time is later about 4 mintues;when the contents of Fructus Evodiae in monogastric volume is equal, Coptidis rhizoma makes the contents of Fructus Evodiae decreased conspicuously.The percent of Coptidis rhizoma accounts more,the contents of Fructus Evodiae decreases more,and the suite of peaks about Fructus Evodiae all in advance about 7 minutes.The Compatibility of Coptidis rhizoma and Fructus Evodiae shows the Fat-degrade effect which is leaded by Alkaloids;And the(1:1) is the best compatibility.Conclusion:This research is objective to provides some scientific reffered evidence to clinical reasonable utilization for traditional prescription.