Nano Codonopsis Mixture To Adjust The Gut Microflora Imbalance Between Prevention And Treatment Of Multiple Organ Dysfunction Syndrome

Objective: We designed the experiment in order to study Nano- dangshen mixture prevent and cure intestinal infection and endotoxemia (IETM), by adjusting dysbacteriosis, repair intestinal barrier function, control bacteria and toxins translocation, in the Multiple Organ Dysfunction Syndrome (MODS).Abating"The Secondary Injury"to MODS, caused by IETM and cell factor chain reaction, to improve the corresponding symptom, and reduce mortality.Method: Selection of 70 Wistar rats, to prepared the rat model of MODS by intestinal ischemia- reperfusion. Intragastric administration with Nano Chinese medicine, Normal Chinese medicine and Bifidobiogen Livzon respectively.Then after one week the animals were killed to detected the changing of bacteria quantity and location, determination of plasma endo- toxin level, intestinal contents level of SIgA, CD4 +, CD8 + counting, and pathology examination.Results: This study to reproduced MODS model successfully, The model group had dysbacteriosis, bacterial and endotoxin translocation, at the same time with two and two or more organ damaged, CD4 + reduction, CD4 + / CD8 + ratio fell even inverted ratio, SIgA level decreased significantly. Compared with the normal group significantly. The therapy groups reduced bacterial and endotoxin translocation significantly, controlled IETM , improved relevance index of pathology and immunity, by regulating intestinal dysbacteriosis, and repairing intestine barrier function.The overall effect, Nano-CM, Normal-CM and Bifidobiogen Livzon were all effective, but Nano-CM was better than Normal-CM, and Bifidobiogen Livzon in the effect of controlling IETM and improving immunity, the difference was significant(p<0.05).Conclusion: The model group has serious dysbacteriosis, bacteria and toxins translocation which is the key factors of MODS occurrence and development. Dangshen mixture prevent MODS by regulating intestinal dysbacteriosis get fairly good effect, by comparing with Normal-CM, Nano-CM, we concluded that the later is more effevtive than the former .