Endometriosis Endometrial Cells In Patients With Er And Pr Expression And Apoptosis Relations

Objective:To probe the pathogenesis of endometriosis(EM) and to attain more understanding of which factors play a crucial role in their growth, by means of the detection of expression of oestrogen receptors, progesterone receptors and apoptosis-associated factors.Methods:Immunohistochemical method and image analysis were employed to quantatify the expression of ER,PR,Bcl-2 and Bax in iectopic and eutopic endometrium in patients with EM. And compared with that in eutopic endometrium from patients without endometriosis.Results:(1)Expression of ER in iectopic and eutopic endometrium of EM is higher than normal, in eutopic endometrium is higher than in iectopic, and in proliferative endometrium is higher than that in secretory(both p﹤0.05). (2) Expression of PR in iectopic and eutopic endometrium of EM is higher than normal(p﹤0.05), but there is no statistical difference between eutopic endometrium and iectopic endometrium. Expression of PR in proliferative endometrium is higher than that in secretory in normal endometrium(p﹤0.05), but there is no statistical difference between proliferative and secretory in iectopic and eutopic endometrium of EM. (3) Expression of Bcl-2 in iectopic and eutopic endometrium of EM is higher than normal(p﹤0.05), in eutopic endometrium is higher than that in iectopic(p﹤0.05). Expression of Bcl-2 in proliferative endometrium is higher than in secretory in normal endometrium(p﹤0.05), but there is no statistical difference between proliferative and secretory in iectopic and eutopic endometrium of EM. (4) Expression of Bax in normal endometrium is higher than in iectopic and eutopic endometrium of EM (p﹤0.05), in iectopic endometrium is higher than in eutopic(p﹤0.05). Expression of Bax in secretory endometrium is higher than in proliferative in normal endometrium(p﹤0.05), but there is no statistical difference between proliferative and secretory in iectopic and eutopic endometrium of EM. (5) Expressions of ER and PR are deranged. Although the expressions of ER and Bcl-2 are both enhance in iectopic and eutopic endometrium of EM, they are uncorrelated. Expressions of Bcl-2 and Bax are also uncorrelated.Conclusions: Expressions of ER and PR in eutopic endometrium are higher than that in iectopic and normal endometrium in both proliferative and secretory endometrium, this makes eutopic endometrium proliferate in low level continuously and easy to move outside and plant. The decreased expression of PR in iectopic endometrium compared with eutopic make PR lose the reactance of estrogen control. Expressions of Bcl-2 and Bax in eutopic and iectopic endometrium have no relationship with endometrical cycle. Endometrium cell's apoptosis weakens and proliferation enhances continuously in EM.