Experimental Study On The Sex Hormones, Sex Hormone Receptors In Pathogenesis Of Irritable Bowel Syndrome

Irritable bowel syndrome is defined as a group of functional bowel disorders in which abdominal discomfort or pain is associated with defecation or change in bowel habit and is associated with features of disordered defecation. A diagnosis is based on identifying the consistent symptoms with the exclusion of other organic or functional disorders having similar clinical presentations in a cost-effective manner. Abnormal colonic and rectal motor functions were regarded as the main pathophysiology of IBS, including altered gastrointestinal motility and increased gut sensitivity. The low grade mucosal inflammation may be involved in the pathophysiology of visceral hypersensitivity. some previous prospective studies reported that 7%-33% of acute bacterial enteritis patients developed IBS after 6-12 months of infection. After enteritis event, the increased number of immunocytes, mast cells and large amount of lymphocytes infiltration were revealed in mucosa and enteric nervous system of the gut. Beside the inflammatory cells, enterochromaffin cells and cytokines may be related to the pathophysiology of IBS. And the abnormality in the gastrointestinal autonomic nervous system can induce constipation or diarrhea.Irritable bowel syndrome (IBS) is more common in women, Women have a higher prevalence of symptoms than men (2:1 ratio). Several lines of inquiry have...