| Functional dyspepsia means abdominal pain,abdominal distension,getting more full for a long time,belch,losing the appetite,nausea,vomiting,such as that upper abdomen symptoms uncomfortable of etc.,excluding from causing a group of clinical syndrome of the organic disease of these symptoms through checking. Symptom breaks out sustainably and repeatedly,the course of disease generally or adds up to for over 12 weeks during December over one month.The statistics show, the morbidity of indigestion digests 2-8 times of ulcer.The epidemiology investigation in America and Europe indicates,the person who has indigestion symptom accounts for 19%-41%in the ordinary crowd,and FD proportion of taking the indigestion patient is up to 30%-50%.According to counting at home,the patient going to a doctor because of indigestion symptom accounts for 30%of the total number of clinic of department of internal medicine,accounts for 70%which digest the specialized department clinic of department of internal medicine,and FD accounts for 30%-40%which digest the specialized department clinic of department of internal medicine.It had already had a history of several thousand years that traditional Chinese medicine treated FD relevant diseases,It had accumulated abundant treatment experience,clinical curative effect that is reliable,it has obvious advantages. According to a large amount of documents and materials and our clinical experience, it has clinical actual meaning and unique superiority that traditional Chinese medicine treats FD,mend and concurrently construct openly more on treating,fever and chills are used simultaneously,make the temper rise and succeed,transport and melt to return to normal,stomach Qi and lowering,diseases with such symptoms as costal pain,etc.are adjusted and reached,it is normal to go up and down,all diseases disappear.According to diet section,feeling cause of disease and originally timid to mark real,will of internal injury,until spleen originally,with the disease machine characteristic marked in fact,in invigorate the spleen benefit at the angry foundation, put product that regulate the flow of vital energy in an position,hard to turn on bitter to lower in order to rush down heart,the heart,in order to subdue ruffians through rushing down.But because the scarce system is studied,its adyantage is not given full play to.We on the basis of summarizing forefathers' experience,combine one's own clinical experience group side and Tiaozhong granule transfer,that become,have already been indicated,it is unique to treat FD curative effect,has been welcomed,by patients.This research is in order to further establish the clinical curative effect of the Tiaozhong granule while adjusting,offer the scientific basis for the fact that it is popularized and applied,adopt the domestic and international and advanced research means at present and go on clinical research,Chinese medicine of probing into FD of the system is managed and ruled by law.1 Study objectiveTo investigate the clinical effect of Tiaozhong granule on patients with Functional dyspepsia2 Study metuodsAccording to FD diagnostic standard in internationally acknowledged RomeⅡand the traditional Chinese medicine clinical research guideline of treating ruffian's full card of new medicine,we had confirmed the diagnostic standard of the clinical observation case,included in the standard,and got rid of the standard..According to these standards,142 of patients divided layer according to sex,age,then every case divided for Tiaozhong granule group transfer,with random digit form law and then, many Pan set up ketone group(70),confirmed the healing solution and curative effect standard,observed the changes of several indexes before and after treating, appraised its curative effect.2.1 Study items2.1.1 The security:Measured and treated front and back blood,urine,excrement routine,the changes of liver,renal function,blood glucose,fat of blood and electrocardiogram.2.2.2 Curative effect:To treat front and back patient for a long time full having abdominal distension,belch,sick vomiting,having abdominal pain,appetite drop 7 symptoms go on,grade,observed every symptom severity and the changes of frequentness and total mark of symptom;It observed tongue like,the pulse elephant one change and for various card type comparison of curative effects;Observed and treated emptying,the changes of the electric picture of stomach,gut hormone of front and back stomach.3 Study results3.1 Security:The Tiaozhong granule to patient's heart,liver,kidney,nonpoisonous side effect of blood system while adjusting,clinical application was safe and effective.3.2 Curative effect3.2.1 Curative effect of clinical curative effect were compared:Two groups of treatment every the last symptom severity and frequentness had improvement in various degree,Tiaozhong granule group clinical cure rate and always efficient to higher than Motilum group more transfer,(P＜0.01,P＜0.05).3.2.2 The value of total mark of front and back symptom of two groups of treatments was compared:The difference of total mark of symptom was prominent(P＜0.01) before and after two groups of treatments,Tiaozhong granule group's curative effect was superior to many Pan and set up ketone group(P＜0.05)while transferring.3.2.3 The tongue wass like comparing with pulse like the change:Two tongue,patient of group,like and alike to have,take a favorable turn obviously treat relatively,treat, in pulse(P＜0.01),Tiaozhong granule group's curative effect was obviously superior to many Pan and set up ketone group(P＜0.01)while transferring.3.2.4 Two groups of Chinese medicine card type curative effect were compared: Transfer in Tiaozhong granule the groups to various the effective,superior to because there aren't many Pan,especially for spleen and stomach types weak,fever and chills are the mixed result the getting more obvious. 3.2.5 The electric rhythm of front and back stomach of two groups of treatments was compared:Treating the first two groups of patients mostly has electric unusual rhythm of stomach,disorderly in order to mainly behave with the electric rhythm of stomach particularly.It was the last to treat can improve by stomach rhythm disorder states electric(P＜0.01)obviously every group,in not transferring superior to Tiaozhong granule group curative effect there aren't many Pan.3.2.6 The electric parameter of front and back stomach of two groups of treatments was compared:Compared with the situation before treating,treated the last electric percentage of two groups of normal stomaches to obviously improve(P＜0.05); Tiaozhong granule group treated superior to Motilum group(P＜0.05)more transfer.3.2.7 The comparison of the remaining rate of front and back stomach of two groups of treatments:Two groups can obviously promote the stomach to empty(P＜0.01), Tiaozhong granule group's curative effect is superior to many Pan and set up ketone group(P＜0.05)while transferring.3.2.8 The front and back stomach of two groups of treatments is moved plainly the gastrin determine the result to compare:Treat the first empty stomach blood plasma MTL and serum Gas level of two groups of patients to obviously drop(P＜0.01)than normal value;It was the last to treat two group patient blood plasma MTL level than rising obviously before treating(P＜0.05),in not transferring superior to Tiaozhong granule group curative effect there aren't many Pan obviously,relatively there was not a prominent difference before and after treatment in serum Gas.4 Study conclusionTiaozhong granule achieved the goal of treating FD through raising MTL of blood plasma,strengthening electric amplitude of the stomach notably,improving electric percentage of the normal stomach,promoting the motive force of stomach, improving the stomach and empty,and it had not found the obvious poisonous side effect in clinical observation. |
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