Hypertension And Insulin Resistance In Progress

Hypertension (essential hypertension, EH) is the highest incidence of a disease, but also heart, cerebrovascular disease the most important risk factor. According to the 2002 residents of nutrition and health survey data show that China's adult prevalence rate of hypertension for 18.8 percent, there are about 160 million patients with hypertension. And its pathogenesis still do not have a complete and unified understanding of the pathogenesis of hypertension now more focused on the following links: (1) sympathetic nervous system activity hyperthyroidism (2) kidney Shuinazhuliu (3) renin - Vascular Of tension - aldosterone system (RAAS) activation (4) the abnormal cell membrane ion transport (5) insulin resistance. In recent years is that insulin resistance in type 2 diabetes and hypertension in the common pathophysiological basis, and type 2 diabetes is atherosclerotic disease a clear risk factors, such as is also the risk of coronary heart disease. When hypertensive patients with type 2 diabetes, cardiovascular and cerebrovascular diseases increase the risk further. In recent years, hypertension and insulin resistance of the cardiovascular research field has become the "hot."Insulin resistance lead to hypertension summed up the mechanism for the following: (1) sympathetic nervous system (SNS): hyperinsulinemia increased sympathetic adrenal system (SAS) and the renin-angiotensin system (RAAS) of the excitement. (2) stimulating vascular smooth muscle cell proliferation and promote atherosclerosis (AS). (3) Shuinazhuliu. (4) endothelial dysfunction. (5) electrolyte imbalance.Hypertension and insulin resistance in the common cause of Chinese medicine can be summed up as emotional disorders, instead of Yu Shu, can lead to falling into Ganqi blues, and the fire Shangyin; their common disease-for Yinxuyangkang. Many studies show that patients with hypertension and IR-TCM there is a correlation between positive and close relationship with the IR. Currently on insulin resistance in patients with hypertension treatment, has not yet formed to target insulin resistance for the more risk factors for the new integrated control strategies, and the prevention of cardiovascular disease as the center of early prevention strategy, this will be our common goal of research and development direction .In clinical medicine to improve insulin resistance in patients with hypertension have made a positive effect, whether it is drugs or non-drug therapy, can improve the different levels of insulin resistance in patients with hypertension, and revealed the Chinese medicine to improve insulin resistance in patients with hypertension are more ingredients, Multi-channel, multi-target integrated, relatively safe, less side effects. But a lot of clinical observation of the lack of rigorous statistical methods, still need a forward-looking, a large sample of clinical studies to complete this work.