| Radioembolization of liver cancer has been proven to be an effective therapy innuclear medicine. The yttrium-90 glass microspheres has been used to treat both primaryand metastatic liver tumors in clinic with encouraging results. By directing radioactivemicrospheres directly into the hepatic artery, a concentrated dosage of radiation can bedelivered directly into the tumor bed, while conserving the normal liver tissue thatsurrounds the tumor. The size of the microspheres causes them to become entrapped withinthe tumor vasculature and retained within the tumor for radioactive therapy.This study prepares radioembolization pharmacy by labeling resin with iodine-125.Two methods are used: 1) label anion exchange resins by ion exchange, and then coat theresin with ploT-L-lactic acid; 2) combine tyrosine with resin, and then label themicrospheres by chloramines treatment (Ch-T).The results of in vitro stability indicate: 1) a large amount of iodine-125 labeled on theanion resin microspheres by ion exchange leaches from microspheres. The stability ofradioactive microspheres can be improved by coating with ploT-L-lactic acid; however,about 60% of the activity leaches from the microspheres in this process, and approximately10% of the activity leaches after washing with saline. Fortunately, 30% of the activityremained stably in the resin microspheres. Keeping the coating resin microspheres in salinefor 8 weeks, only a little activity leaches every week. 2) The radioactive microspheresprepared by chemical synthesis and labeled by Ch-T has a high in vitro stability, with nomore than 1% loading releasing from the microsphers in normal human serum.In conclusion, the radioactive microspheres prepared by chemical synthesis andlabeled iodine-125 by Ch-T can be used to radioembolization therapy, with respect to theirpharmaceutical quality. |
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