Yanbian Area Korean And Han Residents Of Serum Uric Acid Level Study

Objective: To survey and analyze the distributing characteristics of serum uric acid (SUA) and its related factors among Korean nationality (K-nationality) and Han nationality (H-nationality) in Yanbian area.Methods:①Using simple randomized principia, people of K-nationality and H-nationality aged more than 30 years in four towns, Antu of Yanbian were selected from August 2005 to August 2006. The original area and national proportion of people brought into were close, and they knew and agreed the surveying matters.②The surveying related information was collected by visiting home enquiry and health examination in selected community and public health center.③The surveyors were strictly trained before investigation and the inventory content, operative procedure and methods were standardized, and it was carried through to visit home and inquiry with a unitive questionnaire including general status, previous history and family history of cardiovascular diseases, and so on.④The height, body mass index, waistline, hipline and blood pressure etc. were measured.⑤The fasting vein blood in early morning (12 hours of fasting) was taken out, and the SUA, serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose(FBG) etc. were measured.. The upper biochemical indexes were detected with the whole automatic biochemistry analyzer.⑥The measurement data diversity was compared with t-test: the rate was compared withχ~2-test and u-test; the relationship between the hyperuricemia and its related factors was analyzed with the Logistic regression analysis that was performed with hyperuricemia as dependent variables, and nationality, sex, age, hypercholesterolemia, hypo-HDL-C, hypertriglyceridemia, hyperglycemia, hypertension, blood urea nitrogen(BUN), creatinine(CREA), high sensitivity C-reactive protein(HS-CRP), alanine aminotransferase(ALT), aspartate aminotransferase(AST), glutamyl transpeptidase(GTP), body mass index(BMI), waistline, bodyfat and interfat as independent variables, and the variable was selected by the BACWARD method in whichα=0.05 as significant level of selected variable andα=0.10 as significant level of deleted variable.Results: Out of 2375 cases with full results of questionnaire, anthropometry and biochemical index measure, 1068 cases (45.0%) were K-nationality (425 of male and 643 of female), and 1307 cases (55.0%) were H-nationality (465 of male and 842 of female).①For male, the mean level (μmol/L) of SUA was 334.16±123.96 in K-nationality, and that was 318.17±104.55 in H-nationality; for female, that was 250.94±81.44 in K-nationality, and that was 246.39±78.86 in H-nationality. The mean level of SUA was significantly higher in K-nationality than that in H-nationality among male (P＜0.01).②For male, the crude rate of hyperuricemia was 16.2% in the K-nationality and 16.4% in the H-nationality, and 9.7% and 11.0% among female, respectively; the age-adjusted prevalence of hyperuricemia was 17.10% and 14.92% in male, and 7.49% and 10.44% in female, respectively. For male, the age-adjusted prevalence of hyperuricemia in the K-nationality was significantly higher than that in the H-nationality (P＜0.01); for female, that in the H-nationality was significantly higher than that in the K-nationality (P＜0.01).③Among the related factors of hyperuricemia, the mean levels of systolic blood pressure(SBP), diastolic blood pressure(DBP), TC in the female of K-nationality were significantly higher than those in the female of H-nationality (P＜0.05);in both sexes, the mean level of TG in the K-nationality was significantly higher than that in the H-nationality (P＜0.05); in both sexes, the mean levels of bodyfat, interfat, BMI and waistline in the H-nationality were significantly higher than those in the K-nationality (P＜0.05). In the SUAⅠ,Ⅱ,Ⅲ,Ⅳgroups, then compared with each other, the mean levels of TG, low-density lipoprotein cholesterol(LDL-C), CREA, HS-CRP, ALT, AST, GTP, bodyfat, interfat, BMI and waistline had significant differences on male of K-nationality(P＜0.05); the mean levels of SBP, DBP, TG, LDL-C, BUN, CREA, AST, GTP, bodyfat, interfat, BMI and waistline had significant differences on female of K-nationality(P＜0.05); the mean levels of age, SBP, DBP, TG, HDL-C, CREA, ALT, AST, bodyfat, interfat, BMI and waistline had significant differences on male of H-nationality(P＜0.05); the mean levels of age, DBP, TC, TG, LDL-C, CREA, HS-CRP, ALT, AST, GTP, bodyfat, interfat, BMI and waistline had significant differences on female of H-nationality(P＜0.05).④The results of multiple factors analysis showed that the factors selected finally into the equation separately were age, CREA, AST, hypertension, hypertriglyceridemia, bodyfat and interfat on male, and those were BUN, CREA, AST, hypertriglyceridemia, hypo-HDL-C, BMI and waistline on female.Conclusion:①The distributing characteristics of SUA and its related factors among K-nationality and H-nationality in Yanbian area have significant difference.②For male, the hyperuricemia was closely related with age, renal function, liver function, blood pressure, blood-lipid, bodyfat and interfat; for female, that was closely related with renal function, liver function, blood-lipid, BMI and waistline.