| Presently ,the development and using of natural product resources as medicines are come to the world' s attention, more and more natural product resources are needed. Using natural product resources for treating diseases for people' s health has a long history in China , and it promote the development of Chinese traditional medicine. So, enhancing search these resources would be a essential work to medicinal scientists.This thesis search the chemical compounds of Periplaneta Americana L. and Rodgersia sambucifolia Hemsl. Many kinds of silical gel and chromatogram were applied to isolate and purify these two grows .Fifteen compounds were isolated from Periplaneta Americana L. and Rodgersia sambucifolia Hemsl in all, and nine compounds' structures were elucidated by spectral methods. These structures include fatty acid, cumarin, flavone and so on. The results of this project:1. Chemical constituents from Periplaneta Americana L.Periplaneta Americana L. belonging to Cockroach item,and it has many bynames. Periplaneta Americana L. is distributed in Fujian, Guangdong, Hainan, Yunnan, Guangxi, Sichuan and so on.There are many literatures about the effect of Periplaneta Americana L. In China in history, Periplaneta Americana L. is widely used as antivirus, anticancer and enhance immunity in some minor districts in China. Therefore ,It has been used to cure the bump caused by variety reasons .To comprehensively understand the chemical constituents of Periplaneta Americana L., and to make sure the effective partitions and components as antivirus and anticancer, the chemical investigation on Periplaneta Americana L. is necessary. The project use silical gel and chromatogram as the methods of isolation . Six compounds were isolated from Periplaneta Americana L., their structure were elucidated by 1H-NMR, 13C-NMR and DEPT spectra method as: 7-Hydroxycotadecanoic acid (compound 1), Bis(2-ethylhexyl)phthalate (compound 6) .The result shows that: most compounds in Periplaneta Americana are fatty acids.2. Chemical constituents from Rodgersia sambucifolia HemslRodgersia sambucifolia Hemsl belonging to family Saxifragaceae,is distributed inShanxi, Gansu, Ningxia, Sichuan, Yunnan, Henan and so on. Rodgersia sambucifolia Hemsl is widely used as wound, fracture, bleeding in some minor districts of China. Bergenin which was isolated from the roots of Rodgersia sambucifolia Hemsl has the antitussive activities, used to cure chronic bronchitis caused by variety reasons ,and pharmacological characteristics of bergenin are selective check to cough centrum with little side effect. And it has been used in clinic. However ,there are little datas about the chemical compounds of Rodgersia sambucifolia Hemsl which can be used to treatment .To seek for chemical constituents of Rodgersia sambucifolia Hemsl ,and efficiency using in clinic ,this project also applied silical gel and chromatogram to isolate chemical compounds from Rodgersia sambucifolia Hemsl .Nine constituents were isolated from the plant ,their structures were elucidated by spectra method as: gallic acid(compound 1) , 11 -O-galloylbergenin(compound 2), 3,3' ,5' ,5,7-Pentahydroxuflaven(compound 3),3-O- β -hydroxy- δ -8-β -(3,4-dihydroxyphenyl)-penranone(compound 4), 3-O- β -hydroxy- δ -8-α -(3,4-dihydroxyphenyl)-penranone(compound5),Rutin(compound7),Bergenin(compound9). |
