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Formula is the important method of preventing disease in traditional Chinese medicine(TCM),and the main pattern of applying Chinese medicinal materials in clinic."the composing formula mode"plays the important role in acting as theoretical tool of analyzing prescription construction , explaining formula compatibility and creating effective and new prescription on formula-ology,and it is always the primary research contents of formula-ology on TCM.With the development of clinic on TCM,the emerging on combination of TCM with Western medicine and permeation on TCM of much subjects theoretical means,"the composing formula mode"of formula appears on multi-element tendency.Among the total the modern composing formula mode of according to integrated disease,syndrome and symptom takes on clue based on the relation of formula and Chinese medicines.It is compatible with the traditional composing formula mode of"monarch,minister,assistant,and guide"based on the relation of formula and Chinese medicine,and takes on the new composing formula mode of modern formula-ology characteristed with correlation of disease,syndrome and formula,Chinese medicines.The composing formula mode of according to integrated disease,syndrome and symptom is the therapeutic composing formula thinking on emphasizing the correlation of disease-syndrome-symptom,and basing on applying herbs experience combination with diagnosis and treatment based on differentiation of symptoms and signs,mastering of disease or symptom,and consisting with disease-syndrome-symptom.Based on the multi-element composing formula mode, the thesis expounds the logic basis and experience foundation of the composing formula mode of according to integrated disease,syndrome and symptom by analyzing the connotation and correlation of disease,syndrome,symptom; and searching experience case evidence on diagnostic and therapeutic composing formula theory of relation to disease-syndrome in ancient and modern times,and on formula-ology and phamacy experience of exclusive formula and herb,and on showing the composing formula mode of according to integrated disease,syndrome and symptom.On the basis,the author preliminary approaches on basic connotation of the composing formula mode of according to integrated disease,syndrome and symptom,clinic operating technique,and its meaning.Logical basis:It exists the concomitance reality of disease,syndrome and symptom in the diagnostic and therapeutic system of TCM,and has different connotations and exosyndromes respectively.Disease is the organism pathological developing procedure induced by special etiopathogenisis, syndrome is pathological comprehensive diagnosis unit in some special stage of the disease developing course,and symptom is the abnormal and appreciable manifestation of disease and syndrome. Disease is basic or fundamental contradiction in the disease developing course,but syndrome is primary contradiction of disease special stage currently.Disease and syndrome reflect disease essential character from the different angles, but symptom is extrinsic appearance of disease essence.Disease , syndrome and symptom exist comparatively complicated on-of relation on reflecting phenomena of primary or secondary contradiction and disease essence,likewise not only disease and syndrome or disease/syndrome and symptom display intrinsic identity,but also appear different degrees separability in invariable condition and stage.In the course of disease genesis and development,disease and syndrome and symptom have dynamic change character on surrounding disease primary and secondary contradiction,primary and secondary factor of contradiction.It is the importance on the character of entire regulation to composing and therapeutic formula that is grasping correlation of disease,syndrome and symptom and knowing the change of primary and secondary contradiction.Experience evidence:By penetrating investigation on ancient and modern literature,we can discover TCM has the thinking of diagnosis and treatment based on different disease and syndrome in earlier period.Later,because disease and symptom are confused in its conception and connotation , retricted by objective history conditions and diagnosis and treatment based on differentiation of symptoms and signs characteristed with disease phase handle occupies main position,it impaires overall deep exploration on regularity of diagnosis and treatment based on differentiation of disease.After Ming and Qing dynasty,Formation of Science of Warm Disease as cold attack helper in therapeutic system of fibrile diseases and development of integrated traditional and western medicine promote emphasis and exploration on diagnosis and treatment based on differentiation of disease and syndrome again.In modern times,some famous medical scientists put forward theory of primary prescription treating disease and syndrome having different therapeutics,and important discuss on combination of diagnosis and treatment based on differentiation of disease and syndrome.In past dynasties materia medica prescription books have formula and herbs applying record related to aimming directly at disease,syndrome and symptom,it indicates specified herbs and formula aimming directly at certain disease and symptom or basic syndrome and pathogenesis of disease exist actually.In ancient and modern experience cases it has not only many effective cases selected formula and herbs according to syndrome,but also many therapeutic cases according to disease and symptom.the cases integrated with disease and syndrome based on diagnosis and treatment according to specified herbs and formula , and modern phamacological research achievements are obvious.Development stria about diagnosis and treatment based on disease and syndrome,the medical scientist theory about diagnosis and treatment based on disease and syndrome in past dynasties,formula and herbs aimming directly at disease,syndrome and symptom in materia medica prescription books , clinical experience cases implying combination with specified herbs and formula and disease,syndrome and symptom,these can become emphatic evidence on the composing formula mode of according to Integrated disease,syndrome and symptom.Based on correlation of identifying disease,syndrome and symptom,the composing formula mode of according to Integrated disease,syndrome and symptom emphasizes the thinking on combination with applying herbs according to diagnosis and treatment based on disease and syndrome and specified herbs and formula according to disease and symptom,and still emphasizes consideration of dispatching herbs and composing formula.It is the addition to the traditional composing formula mode of"monarch,minister,assistant,and guide",It reflects the Chinese medicine treating principle of appearance and substance and the degree of urgency , giving consideration of main and secondary syndrome , it combinates with modern therapeutic theory of developing diagnosis and therapeutic based on disease and syndrome.this becomes important tool of modern TCM and integrating TCM with western medicine.This composing formula mode is of important meaning for promoting the research of treating disease by differentiating integrated syndrome and symptom,enriching composing formula theory,creating new formula in the clinic. The thesis puts forward technological highlight referring to apply the composing formula mode of according to integrated disease,syndrome and symptom : legislation according to disease and syndrome ,compatibility of formula and medicines.Combination with basic clinic experience on diagnosis and therapeutic based on disease and syndrome presently,the author inducts three fundamental operating types and highlight of the composing formula mode, and trims part specified formula and medicines according to integrated disease,syndrome and symptom by utilizing literature,it provides invariable utilization in order to deeply clinic practice.