Ages On The Relationship Between Pupil Dysfunction And Diabetes

Objective:Mydriasis is important to ocular operations,but mydriasis is not easy for patients with type 2 diabetes .Data from experimental studies have suggested that the increased formation of advanced glycation end products (AGEs) appeared in ocular tissue and blood plasmaAGEs can cause endothelial dysfunction in patients with type 2 diabetes.We study the relationship between AGEs and mydriasis. Materials and Methods:For this study,24 type 2 diabetic patients with difficult mydriasis (A group),21 diabetic patients without difficult mydriasis (B group),and 20 patients without diabetic(C group) were recruited. Plasma AGEs were assayed by competitive enzyme-linked immunosorbent assay.The expression of AGEs in the iris were assayed by immunohistochemistry. Results:Plasma AGEs :There was significant difference between group A (7.625±1.69 u/ml)and group B(5.904±l .27u/ml), P <0.05; There was significant difference between group A (7.625±1.69 u/ml) and group C (3.726±1.35 u/ml ),P<0.05.AGEs expression in iris: There was significant difference between group A (109.13±19.47)and group B( 79.71±13.06),p<0.05;There was significant difference between group A (109.13±19.47) and group C (40.92±11.91),p<0.05. ConclusionIncreased plasma concentrations and the expression in iris of AGEs in type 2 diabetic patients are associated with diabetic difficult mydriasis. Further studies to determine whether treatment targeting AGEs will lead to an amelioration of iris complications are warranted.