Serum Of Scd40l In Patients With Unstable Angina, The Detection Of Gmp-140 And Clopidogrel Intervention

Objective: To observe levels of serum soluble CD40 ligand(sCD40L) and GMP-140 in unstable anigna and the influence of clopidogrel and the clinical effect of clopidogrel.To explore the relationship between sCD40L and GMP-140 and the effect of sCD40L in unstable angigna.Clopigdorel may inhibit the inflammation of atherosclerosis.Method : 59 patients with unstable angina were divided randomly into usual therapy group (29 patients) and clopidogrel group ( usual therapy plus clopidogrel loading dose of 300mg orally and then 75mg daildy for two weeks ,30 patients ).In addition,20 healthy subjects were chosen as healthy control group.Enzyme-linked immynosorbent assay was used to measued levels of sCD40L and GMP-140 in 59 unstable angina patients before and after treatment and in 20 healthy persons,the clinical efficiency of clopidogrel was observed.Result: Levels of sCD40L and GMP-140 were significantly higher in unstable angina (P<0.01) .After treatment ,levels of sCD40L and GMP-140 were significantly decreased in both groups,but the clopidogrel group was more significant than therapy group (P<0.05; P<0.01) .The total effective rate of clopidogrel group was better than therapy group (P<0.05) .Conclusion: sCD40L can stimulate GMP-140 expression and can be used as a marker of plague instability. Clopidogrel can reduce the inflammatory reaction and stabilize plague.