Acute Pancreatitis Assessment Methods Discussed

Background: Acute pancreatitis(AP) is one of most common diseases in alimentary system emergency case. The morbidity has continued to rise in recent years, particularly the mortality of severe acute pancreatitis are still more than 20%-30% , Acute pancreatitis remains a more dangerous disease. So the early predict and correctly assess the severity of acute pancreatitis, which is particularly important to avoid the transformation from mild acute pancreatitis to serious acute pancreatitis in clinical work. Currently, there is still lack of a reliable indicator can objectively evaluate the severity of acute pancreatitis within the initial 24hours of hospitalization. Although the changes of hematoerit(HCT) , platelet count(PLT),mean platelet volume(MPV),platelet distribution width(PDW) and procalcitonin(PCT) within 24h after admission had be reported,It not to be researched in a study to assess the severity of acute pancreatitis and as a diadynamic criteria to discriminate between mild acutepancreatitis (MAP) and severe acute pancreatitis (SAP) .Objective: To find out the relations between etiological factor and the occured and development of acute pancreatitis. To evaluate the relations between the changes of HCT, PLT, MPV, PDW , PCT and the severity of acute pancreatitis.Methods: We collected 172 cases of AP admitted to First Hospital of Shanxi Medical University from year 2004 to year 2006. According to Atlanta criteria divided it into two types : mild acute pancreatitis (MAP) 137 cases and severe acute pancreatitis (SAP) 35 cases . To investigate the etiology, age and sexuality of each enrolled patients.To Record their hematocrit, blood platelet count,mean blood platelet volume , platelet distribution width and procalcitonin were measured within the initial 24hours of hospitalization. The value of each indexes among the mild and severe two groups were compared. To compare the difference value of each diagnostic test between HCT,PCT , HCT connected PCT in series and ApacheⅡas a diadynamic criteria in the synchronization. Results: The severe degree of acute pancreatitis no relevance with the etiology and sexuality of each patient (P >0.05), The patient's age bigger than 55 was more easy to occur SAP (P<0.05). The measured value of HCT,PLT,MPV,PDW and PCT within the 24hours of hospitalization had statistics difference between two groups of MAP and SAP(P<0.01). Every index of the diagnostic test take HCT connected PCT in series as a diadynamic criteria more valid than APACHEⅡ.Conclusion: The severe degree of acute pancreatitis no relevance with the etiology and sexuality of each patients. The patient's age bigger than 55 was more easy to occur SAP. The diagnostic test take HCT connected PCT in series as a diadynamic criteria more valid than APACHEⅡto the early forecased the severity and typing of acute pancreatitis. It's easier to do. Platelet parameters (PLT, PDW and MPV) have changed in initial SAP on, it can reflect the development of acute pancreatitis and to help determine prognosis and guiding treatment.