Ea To Improve Insulin Resistance And Its Mechanism Of Obese Rats

Objective: insulin resistance(IR) is characteristic pathology of obesity and plays a crucial role in the pathological progression of type 2 diabetes and atherosclerosis . Here we explore electroacupuncture treatment whether can alleviate IR of obesity rats that induced by high-fat chew fed SD rats.Materials and methods: male S-D rats were divided into three groups ,each group have 12 rats: F group rats were fed with high fat chew ,NC group rats were fed with normal chew, and I group were administrated electroacupuncture per day of BL20 after 4 weeks fed high-fat chew and persisted to anther 4 weeks At 4 weeks and 16 week and 8 week the euglycemic hyperinsulinemia clamp study was conducted to evaluate the peripheral glucose infusion rate(GIR) in each group. At 8 week, rats serum was collected to assess TC TG FFA. Celiac fat were evaluated and calculated the ratio of celiac fat/body weightResults: In F group, the ratio of celiac fat and body weight was higher than NC group (F vs NC P=0.021), through the interference of electroacupuncture the ratio of celiac fat and body weight in I group rats was significant reduced compared with F group(F vs I P=0.03); The levels of serum TG,TC,and FFA were elevated in F group comparing with NC group(TG: Fgroup vs NC group P=0.000; TC; F group vs NC group P=0.000; FFA: F group vs NC group P=0.001). In I group, TG and FFA level was lower than F group( (I group vs F group P=0.000; FFA: I group vs F group P=0.056 ) The euglycemic hyperinsulinemia clamp study indicated that GIR of F group decreased significant comparing with NC group (F group vs NC group P=0.001) ,but in I group the GIR was increased by interfering with electroacupuncture(I group vs F group P=0.002)..Conclusion: The present study indicated that electroacupuncture of BL20 can decrease celiac fat and improved insulin sensitivity of rats fed with high fat chew. Along with this therapeutic effect the serum concentration of TG and FFAs also been reduced.