| 1.Determination of Isoniazid Using a Gold ElectrodeCompared with the present electrochemical method of determining isoniazid (INH) content by polarography using a hanging mercury electrode, using a gold electrode for determination of isoniazid as proposed by this paper has substantial advantages of convenience, sensitivity, and no pollution. An irreversible anodic peak at ca.-0.3V vs SCE of INH in 0.5M NaOH was used for quantitative determination of INH by cyclic voltammetry (CV) or differential pulse voltammetry (DPV). The peak current showed a linear dependence with INH concentration over the range 2.0×10-6–2.3×10-4 M by DPV with the detection limit of 9.69×10-8 mol/L. The proposed rocedure was successfully applied to the assay of isoniazid tablets. The potential range of CV scan, pH, accumulation potential, accumulation time, interference, and possible response mechanism are also discussed.2. Ion Selective Electrode for the Determination of the Clenbuterol ChlorideA ion selective poly(vinyl chloride) membrane electrode for the determination of the Clenbuterol-choride(CLB), based on the ion-pair complex of clenbuterol with tetraphenylborate as electroactive compound and diisononyl phthalate as plasticizer for the electrode membrane was developed. The electrode showed a linear response with a Nernstian slope of 56.4 mV/pCLB over the range of 1.0×10-1～3.0×10-6 mol/L solution of CLB. And the limits of detection was 8.9×10-7mol/L. Several negative ions and cation and organic solvent don't interfere determination obviously, and this method... |
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