Methotrexate Hydroxychloroquine Together Tongbi I Treatment Of Rheumatoid Arthritis Wind Musculoskeletal 36 Cases Observed

Objective:To investigate the therapeutic effect and adverse reaction of using MTX. HCQ and Prescription Tongbi No.1 together to treat rheumatoid arthritis , which syndrome is wind-cold-damp arthralgia in TCM.Methods:1 Clinical date: All the patients came from Hubei Hospital of TCM,from September ,2005 to December,2005. 72 patients with rheumatoid arthritis ,which syndrome was wind-cold-damp arthralgia in TCM,were divided into two groups at random. Each group had 36 patients.2 The medical usage : The patients in treatment group were treated with HCQ(200mg/d,100mg , po . bid) . MTX(10mg , iv drip , qw) , and Prescription Tongbi No.1(300ml/d,po,bid). The patients in comparison group were treated with HCQ(200mg/d,100mg, po, bid) and MTX(10mg. iv drip, qw).3 The therapeutic effect and adverse reaction : The main clinical symptoms and physical signs were observed and recorded after 8 weeks treatment. But during the research all the patients must be obsearved carefully in order to make the research secure. Indexes in laboratory tests including blood-rt , urine-rt, stool-rt , electrocardiogram, hepatic function, renal function, blood sedimentation rate, rheumatoid factor and C-reactive protein were tested before the research and after 4 weeks or 8 weeks treatment. Then the result of indexes was compared between two groups .4 The statistic method: After four or eight weeks, we analyzed the data. The count materials were examined with X~2.The measuring materials were examined with t-test and the grade materials with Rank sum test.Result:1 The total effective rate of the treatment group was 91.67% and that of the contrast group was 84.38%. Examined with Rank sum test,the treatment group's therapeutic effect was better than the other one's on the whole (P<0.05). The marked effective rate of treatment group and comparison group was 55.56% and 37.25% respectively after 8 weeks treatment, so there was statistically significant difference between 2 groups(P<0.05).2 The main symptoms and physical sign included time of moning stiffness, count of joint tenderness, count of joint swollen, rest pain, average grasp force of both hands. After 8-week treatment, it proved that the result of each index before and after therapy was significantly different in each group (P<0.01). However, in relieving count of joint tenderness, count of joint swollen and rest pain, the treatment group's therapeutic effect is better than that of the contrast...