Dogwood Medicinal Medicine Nux Glycosides Inspection And Honeysuckle Plants Loganin Distribution Study

Part oneFructus corni is dry ripe sarcocarp of Cornus officinalis Sieb.et Zucc.,family Cornaceae. It is one of beneficial traditional Chinese medicine which can be used for invigorating the liver and kidney ,astringing the preserve essence. The medicinal material is mainly produced in Zhejiang, Henan and Shaanxi. Study on the literatures of iridorid glucosides from Fructus corni show that loganin has immunomodulation effect and anti-hemorrhagic shock activity. Loganin determionation in Fructus corni has been include in China PH. Loganin was got by using macroporous resin and classic preparative method. Meanwhile, I also got another components from Fructus corni. and authenticated their structures by the means of spectroscophy(UV, IR, ¹³C-NMR, ¹H-NMR, HMBC, HMQC) .They were 7β-O-methylmorroniside and ursolic acid.We compared the content of loganin in different part and different growing period of Cornus officinalis by HPLC. Besides, through comparing eleven batch of medical materials, we got the fingerprint of the water-soluble components in Fructus corni. By establishing the fingerprint on water-soluble component of Fructus corni, the genuine or fake from the medicinal material was differentiated. In a word, a new method controlling the quality of Fructus corni was established.We also determined the content of loganin in two patent medicine Mingmudihuang pills and Erlongzuoci pills which contained Fructus corni.Part twoLonicera japonica Thunb. belongs to Caprifoliaceae. It was also namedJinyinhua, which is mainly produced in Henan, Shandong and Shaanxi. Study shows that loganin was got from Lonicera. We compared the content of loganin in different part of Lonicera japonica Thunb. by HPLC, and determined the content of loganin in FlosLonicerae and Caulis Lonicerae from different places.