The Fleabane Effective Components Of The Optic Nerve Protection And Calcium Antagonism Correlation

Glaucoma , one of the leading causes of blindness in the world, is defined as an optic neuropathy associated with characteristic changes in the optic nerve. Neuroprotection is one of the difficult problems to resolve in the field of optic science at present. A crucial feature of retinal nerve damage is the progressive deadth of retinal ganglion cells. Resent studies suggested that Calcium antagonist can protect retinal nerves from apoptosis through several ways. Erigeron breviscapus has the function of expelling wind and cold, promoting blood circulation to dredge the collateral and also relieving pain. The main clinical use of it is to treat thrombotic, cardiaovascular , cerebrovascular diseases and so on. Contemporary studies have provided evidence for the neuroprotective effects of E. breviscapus .This study aims at by setting up a sift and appraise method, and revealing whether neuroprotection of E. breviscapus is related to Ca²⁺ antagonistic effect, also finding out the substantial foundation and mechanism of action with neuroprotective effects of E. breviscapus.The methods and results showed as:It was showed that the flavones and caffeoxyl conjugation compounds are active components with Ca²⁺ antagonistic effect in investigatting the effect of E. breviscapus on voltage-dependent Ca²⁺ channel by ⁴⁵Ca transmembrane influx technique.It was proved that all of them can promote retinal neurons to live in vitro, especially the flavones and caffeoxyl conjugation compounds in exploring neuroprotection of E. breviscapus by the culture of rat retinal neuronal cells.It has established a high intraocular pressure model to observe neuro...