New Model Of The Cervical Vertebral Artery Disease Study

Objective:To Set up a kind of new animal's model of Vertebral artery type of Cervical Spondylosis, according to sludged blood hind the method in place with a net;To explore mechanism of the cause of CSA, and the mechanism of treating by drugs.Method : 50 health rabbit (The male and female are half and half) were divided into 2 groups randomly, 8 rabbit as a group is normally, 42 rabbit as another group plan to make CSA model, there is no difference in TCD, ENG, ABR ,etc. among 2 groups, inject into model group rabbit left side neck pheasant's soft tissue by sludged blood 9ml, 42 rabbit were measured by TCD, ENG, ABR, VsEPs, cerebellum Purkinje die cell count From the 2th weeks after injecting, Confirm the model appears. 50 health rabbit were divided into 3 groups randomly From the 3th weeks after injecting, Put 5 animals to death at random after Laser Doppler Flowmetry Electroacupuncture is measured each time, fetch rabbifs cerebellum and cervical vertebra, carry on pathology to observe.Result: it verifies CSA animal's model that From the 2th,4th,6th weeks after injecting, the speed of blood flow of BA, LVA, RVA obviously slow down by TCD, compared with The right side of artery of vertebra, The left side of artery of vertebra whole journey is tiny, tortuous that there are a lot of segments. it verifies CSA animal's model that From the 2th,4th,6th weeks after injecting, the function obstacle of brain stem were found out by ENG, ABR, VsEPs, Laser Doppler Flowmetry, cerebellum Purkinje die cell count. the sibeline group was given to affuse stomach , The function of brain stem and the supplication blood obviously resume by given to affuse stomach that Jingshu particle and Xibiling.Conclusion: The method is successful and feasible by Utilizing part inject blood cause stasis of blood, held in place with a net to hinder form vertebra artery type model, the method is simple and convenient, the security, effectiveness;The model have the characteristics that keep time relatively long, disappear by itself, totally accord with the demands for model of animal. It reveal that the cause of CSA can directly by mechanics balanced, the theory of sympathetic nerve by Irritabled and the theory of machinery oppress participate in forming of CSA.