Acute Cerebral Infarction In Patients With Plasma Lysophosphatidic Acid And Serum Low-density Lipoprotein Cholesterol Level Of Relationship

The paper reports the study detection of the level of plasmalysophophatidic acid (LPA) and low-density lipoprotein cholesterol(LDL-C)among 70 cases of patients with cerebral ischemic attack(ACI), and 30 cases ofhealthy subjects are chosen as control group. The results show that in the earlystage of infarction, LPA is increasing sharply. LPA of ACI changes inaccordance to different parts and degrees of infarction. LPA of cortical branch ofcerebral arteries infarction, boundary infarction, and central branch infarction isdecreasing in order, while LPA in light, medium, severe groups increasessuccessively. But no obvious difference is observed among LDL-C level ofevery group. The experiment result also shows that LDL-C is relatively stable inface to LPA, which is the active site of LDL-C, so the occurrence anddevelopment of ACI is hardly predicted immediately. As a molecular marker, ifLPA increases, it shows that thrombosis process has started. Moreover, the dropof carotid atheromatous(AS)plaque may result in the increase of plasma LPAlevel. It will start the blood coagulation system, block up the artery vessels, andthus thrombus will occur. The higher LPA rises, the more serious the area anddegree of ACI will be. So the LPA level can serve as the diagnosis of ACI, theanalysis of thrombosis process and the evaluation of effect and prognosis. If thewindow time from white thrombosis to red thrombosis is effectively used togive them treatment, the infarction can be avoided. Therefore, a new way todetect and control the level of LPA in the early stage may be provided to restrainthe infarction.