Et, Anp, Cgrp In The Left To Right Shunt Congenital Heart Disease With Pulmonary Hypertension

Objective:To expore the clinical significance of plasma calcitonin gene-related peptide(CGRP),endothelin(ET) and atrial natriuretic peptide (ANP) in pulmonary hypertension associated with congenital heart disease,to study the correlation among plasma ET,CGRP and ANP. Methods:Plasma ET, CGRP and ANP levels were measured by radioimmunoassay at different stages in 32 patients with CHD and 14 normal subjects. The patients with CHD were divided into four groups according to pulmonary artery systolic pressure /system artery systolic pressure (PASP/SAP): high pulmonary flow group (n=8), mild-PH group (n=8), moderate-PH group (n=8), severe-PH group (n=8). Samples were obtained on admission and before cardiopulmonary bypass. Results:①ET of cubital vein plasma in group1,group2,group3 and group4 before operation is significantly higher than that of the control group(P<0.05). The difference between group1 and group2 is not significant(P>0.05).The difference between group2,group3 and group4 is significant(P<0.05):ET of group4>group3>group2. ②The plasma concentration of ANP of cubital vein before operation in group1,group2,group3 and group4 is significantly higher than that of the control group(P<0.05):group4>group3>group2>group1(P<0.05). ③The plasma concentration of CGRP of brachial vein before operation in group2,group3 and group4 is significantly lower than that of the control group(P<0.05):group4