| Purpose: To investigate the effect of Chitosan on traumatic proliferative vitroretinopathy(PVR)in rabbits.Methods: Traumatic PVR was induced in pigment rabbits by intravitreal injection of platelet rich plasma. Subsequently, the eyes received an intravitreal injection of saline(0.1ml),or chitosan(0.1ml)in doses of 5%,10% and 15%.The eyes were examines ophythalmoscopically on distinct days after surgery and the stage of PVR was evaluated.Results: In the control eyes, the retina detached after 10 days, the PVR had progressed to high stage over time. In the eyes injected with chitosan , the PVR also developed, however, the severity of PVR on each days was lower than that in control eyes in that days. PVR was significantly inhibited in groups treated with 10% and 15% chitosan as compared with the control eyes after 5 days (P<0.05). Histological examination of the chitosan-treated eyes disclosed no morphological changes, and ERG analysis revealed no significant functional changes.Conclusion: Intravitreal injection of chitosan is a safe and effective means of reducing traumatic PVR as an initial step in exploring its potential for clinical treatment of PVR. |
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