Heart Failure Particles Clinical Study Of Myocardial Fibrosis In Patients With Chronic Heart Failure

This paper consists of two parts including summary and clinical study. In the part of summary, it was systematically reviewed that the opinion of Traditional Chinese Medicine (TCM) to Heart Failure (HF), the study development of modern TCM to the etiology, pathology, syndrome differentiation , the therapeutical principle and method, prescription and Chinese traditional medicine to HF. It was also reviewed that the new study results of modern medicine to myocardial fibrosis. In the part of clinical study, Studied the XinShuaiKeli for the chronic heart failure sufferer the influence that the myocardial fiber turn. Purpose: Inquiry into XinShuaiKeLi to a Light, medium heart failure sufferer ( heart function Ⅱ,Ⅲ class) sufferer the serum center muscle fiber turns the index sign: PⅢP, LN the influence, and nerve endocrine factor of the variety: BNP , ALD the influence of the level. Method: Choose up to standard 60 of the sufferer of heart failure of sign,( all for stay in the hospital the case), The plait writes the random form, Select the order of sequence that sufferer timeds by go into, enter to treat the set or matched controls random, The matched control give the doctor normal regulations anti- heart failure treat, Treat the set give the doctor normal regulations anti-heart failure treat + XinShuaiKeli,(one bag of everytime, everyday 3 times), Six turnovers are one distances of treat. The treat front, treat measures a plasma after is each in a peptide with ex- collagen of Ⅲ, laminin, LN, aldosterone, level of BNP; Each do a voice with super heart to measure the left ventricle weight index number, EF, SV, CO, the VE/ VA value. The ABC-ELICA method of a peptide with ex- collagen of Ⅲ, laminin, LN, the BNP concentration, The aldosterone adoption projects the immunity method. Effect: (1)XinShuaiKeli set is total and efficient to chronic heart failure is: 96.7%, better than 83.3% of matched control (P<0.05). (2) XinShuaiKeli set has better improvement action to the syndrome of odour debility and blood stasis, Among them stuffy in the palpitation, thoracic cavity, short and tired aspect of odour, better than matched control(3) XinShuaiKeli can raise the ejection fraction( EF), stroke volume( SV) of the suffensr of heart failure obviously, each output the quantity( CO), the E, A specific value( E/ A) separately, Raise the relaxation contraction function of the sufferer of heart failure, surpass the matched control. (P<0.05). XinShuaiKeli can turn down the left ventricle weight index number of the sufferer of heart failure, better than matched control. (P<0.05). (4)XinShuaiKeli can turn down the plasma of the sufferer of heart failure in a peptide with ex- collagen of Ⅲ, laminin LN,...