The Expansion Of Animal Models Of Schizophrenia And Related Genes And Drug Screening Applications

Based on MK-801-induced animal model of schizophrenia thatproduced in our laboratory earlier, we studied the exploratory abilityand pain reaction of schizophrenia-like mouse. The results showthat the times of poking into holes of model mouse decreasesignificantly in the hole board test, and they also need relativelylonger reactive time in tail-flick test. Treatment with atypicalantipsychotic drugs such as Risperidone and Olanzapine couldinhibit these effects, which further proves the reliability of ourdisease model. Combined with Antisense Oligo assay, weconstructed a platform to screen schizophrenia-related genesbased on our mouse model and tested five candidate genes with it,among which two experiment groups differed significantly fromcontrol groups in openfield movement and stereotype. These twogenes related then could be considered to be related to the diseaseand could be chosen for further studies. Treatment withneuropeptide drug GNTI could also inhibit schizophrenia-likesymptoms such as hyperlocomotion, which shows both theanti-schizophrenia effects of the drug and the possibility of usingour mouse model in screening new drugs.