Acupuncture Adjuvant Arthritis In The Distribution Of Cyclic Adenosine Monophosphate Content And Tetramethylpyrazine In Rats Tend To Experiment

OBJECTIVE: To observe the influence of acupuncture on TMPH topotaxis in advinuvant arthritis rats, then further elucidate a possible role of the, change of cAMP level within the target organs in the mechanism of this phenomenon.METHODS: Adjuvant-induced arthritis rats were treated with acupuncture therapy, Chinese herb treatment or both in combination for one week, then the density of TMPH in heart, liver, kidney, and hind paw was determined by HPLC. The cAMP level in the heart and liver was also measured by radioimmunoassay. The blood changes were detected through the test of blood rheometer.RESULTS: Compared with acupuncture and Chinese herb used separately, acupuncture and herb combination significantly decreased the level of reduced viscosity in whole blood, plasma viscosity, blood sedimentation and erythroagglutination index. .Significant increases of TMPH in the heart, liver and hind paw tissue exceptkidney were observed after the combined treatment, which also raise cAMP level in heart and liver.CONCLUSION: Stimulating certain point(s) can cause topotaxis on certain drug' s absorption in rats, and cAMP may have collaborating mechanism in this process.