| OBJECTIVE: To research the mechanism of the Chinese Compound Prescription ?XuanFuDaiZheTang (XFDAT) treating the gastrointestinal side effect of cancer chemotherapy on rats by using cisplatin(DDP).METHODS: First the rat model of the gastrointestinal side effect with chemotherapy was applied by administering DDP. Then the two treating groups were given high-dose and middle-dose XFDZT by intraperitoneal infusion respectively, while the chemotherapy model group and the control group were given normal saline. After 4 days' treatment, except the control group, the other three groups were administered DDP once again .During the experiment the food consumption of every rat for every day , the gastric mucosal lesion score, the muscular tension of duodenum, theMalondialdehyde(MDA) in the duodenum , gastrointestinal tract hematoxylin-eosion staining were observed .the5-hydroxytryptamine(5-HT) and substance P (SP) expression were both determined by immunohistochemical method. REAULTS: the middle-dose XFDZT can lead to the decrease of thefood consumption, gastric mucosal lesion , the rise of 5-HT and SP expression in duodenum, the increase of contract frequency of duodenum in vitro, the improvement of MDA on small intestine. CONCLUSION: Administering DDP can make the rat model of the gastrointestinal side effect with chemotherapy. The middle-dose of XFDZT could relieve the DDP-induced gastrointestinal side effects . Possibly the mechanism is related to protecting the gastrointestinal mucosa, decreasing the releasing of 5-HT and SP, and regulating small intestine contract, relieving the lipid peroxidation in small intestine. |
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