Adjust The Effect Of Electroacupuncture On Acute Cerebral Vascular Hemorrhage In Rats

Objective:To investigate the pathophysiological significance of change in plasmaendothelin (ET) and calcitonin gene-related peptide (CGRP) levels in rats withexperimental intracerebral hemorrhage during acute period . To study thetherapeutic effection of electroacupuncture (EA) on Intracerebral Hemorrhage(ICH) model rats and the possible functional pathways.Methods:Experiments were performed on 130 SD rats who were randomly divided into four groups: normal group, model group, control group, electroacupuncture group . Each group was subdivided 3 groups according to time except for normal group . Rat model of acute intracerebral hemorrhage was made by Ren' s method. ET and CGRP levels in plasma were dynamically measured by radioimmunoassay.Results:ET level in the experimental group were significantly higher than that in the control group at various time points (at 6 hours,p<0.05;at 24 hour,48 hours and 72 hours ,all p<0.01); ET levels in the experimental group were also markedly higher compared to the normal group (p<0.01) .Similarly ,plasma CGRP levels were obviously higher than that in the controls during the observation period (at 6hours ,p<0.05; at 24 hours ,48 hours and 72 hours ,all p<0.01),and it was significantly higher at 24 hours compared to the normal group (P<0.05).Conclusions:Both plasma ET and CGRP levels alevated during acute intracerebral hemorrhage and they were positively correlated with the degree of brain damage. These data suggest that ET and CGRP may play an important role in the pathological response to acute intracerebral hemorrhage. The result suggested electroacupuncture can regulate the plasma levels of ET and CGRP.